TITLE: NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
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Prompting pregnancy without gonadal LHR
Two gonadotropic hormones called leutinizing hormone (LH) and follicle-stimulating hormone (FSH) control normal fertility. LH can bind to receptors located in the gonads, these receptors (LHR) are also found in other tissues including the brain, uterus, cervix, and more. In a study appearing online on June 9 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Tomi Pakarainen and colleagues from University of Turku address the long-standing question of the role of non-gonadal LHR in reproductive function. The authors transplant normal ovarian tissue into mice lacking LHR and examine reproductive functioning: fertility, pregnancy, litter size, parturition, and lactation. The authors show that non-gonadal LHR, at least in mice, are not required for pregnancy.