Cryptococcus neoformans. In the March 1 issue of the Journal of Clinical Investigation, John Panepinto and colleagues from the University of Illinois at Chicago describe a new class of proteins and a signaling network used by the fungus to wreak havoc. They pinpoint a protein called Vad1 (virulence-associated DEAD box RNA helicase-encoding protein) as a regulator of virulence genes. The paper provides new and important information on how the fungus Cryptococcus neoformans causes disease. In an accompanying commentary, Lena Heung and Maurizio Del Poeta state, "results from future studiesmay be the key to effectively clearing cryptococcal infections and improving quality of life for many patients."
TITLE: The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans
AUTHOR CONTACT:
John Panepinto
University of Illinois at Chicago, Chicago, IL USA
Phone: 312-996-8068; Fax: 312-996-5704; E-mail: panepijc@uic.edu
This article is available at: http://www.jci.org/cgi/content/full/115/3/632
ACCOMPANYING COMMENTARY:
TITLE: Unlocking the DEAD-box: a key to cryptococcal virulence?
AUTHOR CONTACT:
Maurizio Del Poeta
Medical University of South Carolina, Charleston, SC USA
Phone: 843-792-8381; Fax: 843-792-8565; E-mail: delpoeta@musc.edu
This article is available at: http://www.jci.org/cgi/content/full/115/3/593
PHYSIOLOGY
Kallikrein mutations make arteries abnormal
Artery function is known to depend on lipid genetics, but other genetic factors that affect arterial physiology are poorly documented. In a study appearing in the March 1 issue of the Journal of Clinical Investigation, Michel Azizi and col
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Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Mar-2005
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