HOME >> BIOLOGY >> NEWS
JCI table of contents March 1, 2005

EDITORS' PICK:

Defensins ward off HIV in two ways

The body attempts to protect itself from HIV infection via the innate immune system. Defensins are proteins found in cells, which have been shown to have anti-HIV activity. However, the mechanism by which the defensins control HIV infection has not been known. Appearing online on February 17 in advance of publication in the March 1 print edition of the Journal of Clinical Investigation, Theresa Chang and colleagues from Mount Sinai School of Medicine analyze how alpha-defensin-1, in particular, inhibits HIV infection in CD4+ T cells. CD4 + T cells are white blood cells that have molecules called CD4 on their exterior. They help orchestrate the body's response to viruses and therefore play important roles in the immune system.

The researchers show that alpha-defensin-1 fights HIV in two different ways. Without serum (the watery portion of blood that remains when blood cells are removed) and under conditions where viral burden is low, alpha-defensin-1 directly inactivates HIV virus. When serum is present, alpha-defensin-1 acts on vulnerable cells to block HIV infection at the stage when the virus is taken up by the cell and begins replicating itself and integrating into the host. The authors also show that the way alpha-defensin-1 blocks HIV infection in cells is by inhibiting a CD4+ cell-signaling molecule called PKC.

The finding that alpha-defensin-1 acts on both the virus and the cell offers insights into the function of alpha-defensin-1 in innate immunity against HIV. In addition, this study provides a basis to develop defensin-like drugs for prevention of HIV and for therapeutic use in patients who are already infected.

TITLE: Alpha-defensin-1 has a dual role in anti-HIV-1 innate immunity: effects on the virion and the cell

AUTHOR CONTACT: Theresa L. Chang
Mount Sina
'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
17-Feb-2005


Page: 1 2 3 4 5

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2018)... ... December 18, 2018 , ... CP Merritt is a ... been competing for many years however in 2006, he had a medical setback that ... was determined that he suffered from cartilage degeneration in his right rear fetlock. ...
(Date:12/13/2018)... ... December 12, 2018 , ... Illumina, Kaiser Permanente, ResMed and Aetna were just ... Diego-based team-building and cooking events company has hosted an impressive guest list of Fortune ... , Each group who visits receives a completely customized experience, right down to ...
(Date:12/6/2018)... ... December 06, 2018 , ... Stewart has been ... contract services, throughout his career. During his recent five-year tenure with InSphero he ... established the commercial laboratory operations in Brunswick, Maine. Through these experiences, Stewart has ...
Breaking Biology News(10 mins):
(Date:1/10/2019)... ... ... adopted from a local shelter when he was around two years old. According to ... after he was adopted, he tore his right cruciate ligament. Though he had his ... a traumatic injury. , Sure enough, when Rascal was about nine years old, he began ...
(Date:1/8/2019)... ... 08, 2019 , ... The American Society of Gene and Cell Therapy’s ... selection committee made up of industry leaders identified by the ASGCT board of directors. ... awards created to support ASGCT members designing transformative pilot studies in gene and cell ...
(Date:1/4/2019)... SUNNYVALE, Calif. (PRWEB) , ... January 02, 2019 ... ... a proprietary technology to detect precancer and cancer cells in blood, has been ... Medigen Biotech , a global biotech company developing cell therapies for cancer treatment, ...
(Date:12/19/2018)... ... 19, 2018 , ... RURO, Inc., a leading provider of ... 7.1. The new release enhances the latest version of Limfinity®, RURO’s software framework, ... end. , Validation protocols, and their execution, are critical for software systems scrutinized ...
Breaking Biology Technology:
Cached News: