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JCI table of contents November 1, 2004

ber of alveolar cells that underwent programmed cell death, and had more prominent bronchoalveolar inflammation. Microarray analysis provided evidence of about 50 Nrf2-dependent antioxidant and cell-protective genes in the lung that might function together to protect the lung from cigarette smoke-induced emphysema. These data suggest that the Nrf2 pathway provides protection from emphysema by turning on antioxidants and suppressing inflammation and cell death in the lung.

TITLE: Genetic ablation of Nrf2 enhances susceptibility to cigarette smokeinduced emphysema in mice

AUTHOR CONTACT:
Shyam Biswal
Johns Hopkins University, Baltimore, MD 21205, USA
Phone: 410-955-4728; Fax: 410-955-0116; E-mail: sbiswal@jhsph.edu

View the PDF of this article at: https://www.the-jci.org/press/21146.pdf


Ethical Paradigm: Relating Embryonic Stem Cell Use to Organ Donation

The conflict over allowing the creation of embryonic stem cells for therapeutic purposes pits the value of early human life against that of potentially life-saving therapies. This has deeply polarized each side of the argument, ultimately resulting in an arena that disregards common interest or points of view. Donald Landry and Howard Zucker, of the University of Columbia, now offer a commentary that presents a potential means for creating common ground in this debate. The authors propose applying the ethics and standards of organ donation, which has a long history of debate, legal definition, and ethical resolution, to that of embryonic cell use. Landry and Zucker detail the development of laws and practices surrounding the establishment of the definition of death for a fully developed human. At the point that brain function is irretrievably lost, even if other cells and organs remain alive, humans are considered organismically dead. At this
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Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Nov-2004


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