JCI table of contents November 1, 2004

cancer cell lines and found that it was markedly lower both in cell culture and in implanted tumors in mice. The authors then put the SEMA3F gene into human melanoma cells. In culture, these cells had a reduced ability to adhere to and migrate on fibronectin, a standard test of cellular motility. For analysis in live animals, the authors implanted these SEMA3F-expressing tumor cells in mice. In drastic contrast to the tumors whose cells did not contain SEMA3F, the SEMA3F-containing tumors did not metastasize. Furthermore, the resultant primary tumors resembled benign nevi that had reduced vascularization and had an increased number of cells that underwent programmed cell death. Hyperplasia was inhibited in overlying epidermal cells, and the tumors were encapsulated in well-defined thick layers of fibroblast and collagen matrix. Together, these data indicate that SEMA3F is a strong inhibitor of metastasis that affects both tumor and stromal cells, which suggests that it may have therapeutic potential.

TITLE: Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

Michael Klagsbrun
Harvard Medical School, 300 Longwood Ave Boston, MA 02115, USA
Phone: 617-919-2157; Fax: 617-730-0233; E-mail: michael.klagsbrun@childrens.harvard.edu

View the PDF of this article at: https://www.the-jci.org/press/21378.pdf


Cellular Markers of Aging Identified

TITLE: Ink4a/Arf expression is a biomarker of aging

Norman E. Sharpless
The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Phone: 919-966-1185, or 919-966-4067; Fax: 919-966-8212; E-mail: nes@med.unc.edu


Contact: Laurie Goodman
Journal of Clinical Investigation

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