JDRF forms partnership with M...( New York NY and Rockville MD Januar...)

JDRF forms partnership with MacroGenics

New York, NY and Rockville, MD January 3, 2007 -- The Juvenile Diabetes Research Foundation, the world's leading charitable funder of type 1 diabetes research, announced today that they have formed a partnership with MacroGenics, Inc., a Maryland-based biotechnology company that specializes in developing therapeutics for autoimmune diseases, cancer and infectious diseases.

Through this new partnership, JDRF is providing up to $2 million in funding for the "Protg" trial: a multinational Phase II/III clinical trial of a proprietary MacroGenics compound that has shown promise in slowing the progression of type 1 diabetes in children and adults newly diagnosed with the disease. Specifically, the trial will test teplizumab, an anti-CD3 antibody capable of reducing the autoimmune attack that destroys insulin-producing beta cells. In addition, JDRF will also fund research at Yale University, to be conducted by Dr. Kevan Herold, to analyze samples from the Protg trial.

"MacroGenics and Dr. Herold have the opportunity to move anti-CD3 research forward significantly," said Richard Insel, M.D., JDRF Executive Vice President for Research. "At this time, anti-CD3 treatment is the only developed method of changing the clinical course of new onset type 1 diabetes. Because it preserves beta cell function in newly diagnosed patients, anti-CD3 treatment has the potential to decrease insulin requirements, lead to better glucose regulation, and decrease short-term and long-term complications of diabetes. Furthermore, JDRF is especially excited about our partnership with MacroGenics because the Protg trial is one of the first Phase III trials we've ever funded."

JDRF is partnering with MacroGenics through its innovative Industry Discovery and Development Partnership program. The Industry Discovery and Development Partnership program allows JDRF to partner with pharmaceutical, biotech, and medical device businesses who are looking to develop
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Contact: Eileen Brangan Mell
ebrangan@jdrf.org
212-479-7577
Juvenile Diabetes Research Foundation International
3-Jan-2007

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