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JDRF forms partnership with MacroGenics

ope of the CD3-epsilon chain expressed on mature T cells.

In a June 2005 publication in the journal Diabetes, Dr. Herold reported two-year follow-up data for 21 subjects who received a single course of hOKT3-gamma-1 (Ala-Ala) within six weeks of their diagnosis of type 1 diabetes. The patients who received hOKT3-gamma-1 (Ala-Ala) had improved C-peptide responses following a mixed meal tolerance test, reduced hemoglobin A1c (HbA1c) levels, and lower insulin requirements for at least two years following the initial treatment compared to the control population. C-peptide responses measure a patient's residual beta cell function and ability to produce insulin. HbA1c is a measure of metabolic control that reflects the amount of glucose in a patient's blood over a three-month timeframe. Dr. Herold is an advisor to MacroGenics for further clinical testing of teplizumab.

About Type 1 Diabetes

Type 1 diabetes is an autoimmune disease in which the body's immune system attacks and destroys the insulin-producing cells of the pancreas. Type 1 diabetes strikes suddenly, making a person dependent on injected or pumped insulin for life, and carrying the constant threat of devastating complications such as heart and kidney disease, nerve damage and blindness. As many as three million Americans may have type 1 diabetes and each year over 13,000 children are diagnosed with type 1 diabetes in the U.S. Although diagnosis most often occurs in childhood and adolescence, it can and does strike adults as well. To stay alive, people with type 1 diabetes must take multiple insulin injections daily or continually infuse insulin through a pump, and test their blood sugar by pricking their fingers for blood six or more times per day. While trying to balance insulin doses with their food intake and daily activities, people with this form of diabetes must always be prepared for serious hypoglycemic (low blood sugar) and hyperglycemic (high blood sugar) re
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Contact: Eileen Brangan Mell
ebrangan@jdrf.org
212-479-7577
Juvenile Diabetes Research Foundation International
3-Jan-2007


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