Jackson Laboratory joins National Centers for Systems Biology

Bar Harbor, Maine - A $15.1 million National Institutes of Health (NIH) grant has been awarded to a team of Jackson Laboratory researchers with a new, "systems" approach to studying the genetics of health and disease.

The National Institute of General Medical Sciences (NIGMS) is awarding the five-year grant for $15,073,585 under a "National Centers for Systems Biology" program. The new center's goal: to understand how the 30,000 or so genes every human is born with interact to develop a healthy individual or lead to diseases.

"The Jackson center will exploit the power of the mouse model to shed light on how complex traits evolve," says Jeremy M. Berg, Ph.D., director of NIGMS. "The combination of systems biology, statistical genetics and genomics promises to yield important insights into common human diseases."

Jackson Senior Staff Scientist Gary Churchill, the principal investigator on the grant, explains: "Heart disease, cancer, Alzheimer's disease, obesity and diabetes -- the diseases that represent our nation's greatest public health burden -- are all extremely complex and may involve hundreds of different genes, as well as diet and other environmental factors."

Using innovative computational approaches, Churchill and Jackson collaborators have made important progress in understanding how the mouse genome is organized overall. Starting with this "big picture" perspective, they plan to zero in on clusters of genes that are associated with complex diseases. "It turns out that most of those genes, individually, are perfectly benign," Churchill says. "It's only in certain combinations that these diseases arise."

The research world uses laboratory mice to study genetic diseases because mice and humans share the vast majority of their genes. Different inbred families or "strains" are somewhat analogous to different human populations, so scientists can study what combinations of genes are more likely to cause, say, hypertension.

Contact: Joyce Peterson
Jackson Laboratory

Page: 1 2

Related biology news :

1. Jackson Laboratory researcher receives JDRFs Grodsky award
2. High BMI doesnt always spell obesity, Jackson Laboratory researchers show
3. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
4. Story tips from the Department of Energys Oak Ridge National Laboratory
5. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
6. Los Alamos National Laboratory making progress in Groundwater Protection Program
7. Bigelow Laboratory Scientists develop new approach to study marine microbes
8. Story tips from the Department of Energys Oak Ridge National Laboratory, April 2007
9. Story tips from the Department of Energys Oak Ridge National Laboratory, March 2007
10. Story tips from the Department of Energys Oak Ridge National Laboratory
11. Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer

Post Your Comments:

(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) ... and aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: ... supporting the organization’s initiatives and overall vision. , "Senior Fellows are more than ...
(Date:6/25/2020)... , ... June 24, 2020 , ... ... enterprise software and software-driven clinical data services that accelerate drug development, is collaborating ... selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter ... of a successful study, while protecting and accessing the catheter or device post-surgery is ... from Envigo in a live webinar on Wednesday, August 5, ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign ... detection and prevention of high-burden diseases, and Centric Consulting, a business and technology ... to utilize existing data in order to identify and prioritize patients for care. ...
(Date:7/10/2020)... ... 2020 , ... Bode Technology, a leading provider ... through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical testing ... provides a turnkey solution that includes a comprehensive collection and virus-management program for ...
(Date:7/10/2020)... ... July 09, 2020 , ... In ... commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to ... by Dr MA has been using the zebrafish model to investigate the causes ...
Breaking Biology Technology:
Cached News: