Japanese researchers get to the heart of atherosclerosis

SAN DIEGO, Calif.--Using positron emission tomography (PET), the medical isotope 15O-water and cold pressor tests, Japanese researchers were able to detect the beginnings of atherosclerosis--before the disease became clinically evident. These results were released during SNM's 53rd Annual Meeting June 37 in San Diego.

This revelation will allow physicians to advise high-risk patients--who show no cardiovascular symptoms--to make lifestyle changes modifications or to undergo medical treatment, said Masanao Naya, a physician at Hokkaido University Graduate School of Medicine in Sapporo, Japan. In addition, researchers determined that elevated levels of interleukin-6--one of the inflammatory chemicals produced by endothelial cells and that has been associated with an increased risk of heart disease--is "a major determinant" of coronary endothelial dysfunction, especially in individuals with high blood pressure.

Atherosclerosis is a slow, progressive disease that begins with damage to the innermost layer of the artery--the endothelium--and buildup of fatty substances, cholesterol and cellular waste products in the inner linings of arteries, which carry oxygen-rich blood to the heart, brain and other parts of the body. The endothelium can be damaged by such factors as elevated levels of cholesterol, high blood pressure (hypertension), smoking and obesity. Over time, plaques can narrow coronary arteries, allowing less blood to flow to the heart muscle. Rupture of these plaques may result in heart attack and death, said the co-author of "Determinants of Coronary Endothelial Dysfunction in Hypertensive Patients."

Coronary endothelial dysfunction--which occurs when blood vessels aren't flexible enough to expand in response to increased blood flow--is the central feature of this dreaded disease. Coronary endothelial dysfunction precedes cardiovascular events and is reversible, making its early detection important, said Naya. He explained, "We can sel

Contact: Maryann Verrillo
Society of Nuclear Medicine

Page: 1 2

Related biology news :

1. Montana State University researchers to compare Montana, Japanese copper mines
2. Carnegies Global Ecology inks partnership with Japanese satellite firm
3. Japanese women found to have lower recurrence of breast cancer
4. GroPep announces Japanese approval of biopharmaceutical that uses its cell culture products
5. Interactive health information system to detect Japanese encephalitis in Asia
6. Innovative tagging technique may help researchers better protect fish stocks
7. Penn researchers discover how key protein stops inflammation
8. ASU researchers partner with UOP to make biofuel for military jets a reality
9. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
10. Penn researchers discover pathway that eliminates genetic defects in red blood cells
11. U-M researchers find family of on switches that cause prostate cancer

Post Your Comments:

(Date:8/21/2020)... ... August 19, 2020 , ... ... expo uniting life science, data science, informatics and IT leaders goes VIRTUAL and ... period of uncertainty and change, Bio-IT takes the leadership role of keeping our ...
(Date:8/7/2020)... , ... August 06, 2020 , ... ... participate in the prestigious National STEM Scholar Program, a unique professional development program ... and project support for middle school science teachers nationwide. , Created in partnership ...
(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life Sciences ... compliance, announces a new solution to manage regulated workloads on Microsoft Azure. , ... technology stack complies with FDA and global regulations. USDM's new managed service for ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... HONG KONG (PRWEB) , ... July 09, 2020 ... ... chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in ... years, the PolyU research team led by Dr MA has been using the ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced ... Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the ... awards program, highlighting outstanding examples of how technology innovations and strategic initiatives can ...
(Date:7/1/2020)... Colo. (PRWEB) , ... June ... ... of expert tissue data insights, today announced that the launch of a ... results along with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight ...
(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... ... to advance photodynamic therapy for treating cancer, today announced the company has entered ... (“Roswell Park”). The agreement provides Lumeda globally exclusive rights to Roswell Park ...
Breaking Biology Technology:
Cached News: