HOME >> BIOLOGY >> NEWS
Jefferson researchers' discovery may change thinking on how viruses invade the brain

(PHILADELPHIA) -- A molecule thought crucial to ferrying the deadly rabies virus into the brain, where it eventually kills, apparently isnt. The surprising finding, say researchers at Jefferson Medical College in Philadelphia, may change the way scientists think about how central nervous system-attacking viruses such as herpes viruses invade the brain and cause disease.

According to Matthias Schnell, Ph.D., professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University, viruses such as rabies must be actively transported to the brain and central nervous system. The LC8 protein was thought to tether viruses to the cellular transport machinery in order to get there.

But Dr. Schnell and his co-workers found that this protein complex is instead a "transcription factor" that plays a role in virus reproduction. "We think that this finding has implications not only for rabies but many viruses that previously were thought to use this complex for transport, such as herpes viruses," he says. They report their results online this week in the journal Proceedings of the National Academy of Sciences.

To understand the role of LC8 in rabies disease in the brain, the team compared a rabies virus strain with the LC8 "binding domain" (where the rabies virus and LC8 protein interact) to a virus lacking it. They showed that in mice that were infected with rabies without the LC8 binding domain, the virus was still able to infect the brain, but did not cause disease. The virus ability to reproduce was greatly diminished.

"What we found has nothing to do with transport," Dr. Schnell says. "We saw that the virus was weakened if we removed the LC8 binding site and viral replication and transcription were affected. But we didnt find a difference in the initial viral entry in the central nervous system. We actually saw that the virus replicated better with the binding site than without it. LC8 is a transcripti
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
19-Apr-2007


Page: 1 2

Related biology news :

1. Jefferson scientists patent dramatically improves
2. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
3. Tiny genes may increase cancer susceptibility, Jefferson scientists find
4. Jefferson scientists use gene therapy to reverse heart failure in animals
5. Jefferson scientists identify protein key to breast cancer spread, potential new drug target
6. Jefferson scientists find rabies-based vaccine could be effective against HIV
7. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
8. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
9. Jefferson scientists find guardian genes choices crucial to stopping cancer process
10. Jefferson researchers uncover new way nature turns genes on and off
11. Jefferson researchers develop combined procedure for uterine preservation in treating fibroids

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... Del. (PRWEB) , ... July 08, 2019 , ... ... Court ruled in favor of Danisco’s ownership of the innovation behind two Danisco ... that an entitlement action could be based on prior art was without merit ...
(Date:6/27/2019)... ... June 27, 2019 , ... Lighting designers from integrated ... Society (IES), which honored the designers for creating both engaging and energy efficient lighting ... Street , an office tower in San Diego, California earned an IES Illumination Award ...
(Date:6/24/2019)... , ... June 24, 2019 , ... According to the ... one of the four most common STDs: chlamydia, gonorrhea, trichomoniasis (or "trich") and syphilis. ... that gay and bisexual African American men accounted for the largest number of HIV ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World ... Corn Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. ... process using field corn to produce biobased materials. , “Corn is a sustainable, ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured ... focuses on regenerative veterinary medicine as a means of improving the quality of life ... the Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it ...
(Date:6/18/2019)... , ... June 17, 2019 , ... ... they have entered into an agreement for production and manufacturing of GMP-grade adeno-associated ... treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
Breaking Biology Technology:
Cached News: