HOME >> BIOLOGY >> NEWS
Jefferson researchers' discovery may change thinking on how viruses invade the brain

(PHILADELPHIA) -- A molecule thought crucial to ferrying the deadly rabies virus into the brain, where it eventually kills, apparently isnt. The surprising finding, say researchers at Jefferson Medical College in Philadelphia, may change the way scientists think about how central nervous system-attacking viruses such as herpes viruses invade the brain and cause disease.

According to Matthias Schnell, Ph.D., professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University, viruses such as rabies must be actively transported to the brain and central nervous system. The LC8 protein was thought to tether viruses to the cellular transport machinery in order to get there.

But Dr. Schnell and his co-workers found that this protein complex is instead a "transcription factor" that plays a role in virus reproduction. "We think that this finding has implications not only for rabies but many viruses that previously were thought to use this complex for transport, such as herpes viruses," he says. They report their results online this week in the journal Proceedings of the National Academy of Sciences.

To understand the role of LC8 in rabies disease in the brain, the team compared a rabies virus strain with the LC8 "binding domain" (where the rabies virus and LC8 protein interact) to a virus lacking it. They showed that in mice that were infected with rabies without the LC8 binding domain, the virus was still able to infect the brain, but did not cause disease. The virus ability to reproduce was greatly diminished.

"What we found has nothing to do with transport," Dr. Schnell says. "We saw that the virus was weakened if we removed the LC8 binding site and viral replication and transcription were affected. But we didnt find a difference in the initial viral entry in the central nervous system. We actually saw that the virus replicated better with the binding site than without it. LC8 is a transcripti
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
19-Apr-2007


Page: 1 2

Related biology news :

1. Jefferson scientists patent dramatically improves
2. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
3. Tiny genes may increase cancer susceptibility, Jefferson scientists find
4. Jefferson scientists use gene therapy to reverse heart failure in animals
5. Jefferson scientists identify protein key to breast cancer spread, potential new drug target
6. Jefferson scientists find rabies-based vaccine could be effective against HIV
7. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
8. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
9. Jefferson scientists find guardian genes choices crucial to stopping cancer process
10. Jefferson researchers uncover new way nature turns genes on and off
11. Jefferson researchers develop combined procedure for uterine preservation in treating fibroids

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2019)... ... 16, 2019 , ... LeadingBiotech , an exclusive event ... its NY/NJ CEO conference to be held on November 5, 2019 ... The event offers senior-level industry leaders a unique opportunity to collaborate, build partnerships ...
(Date:10/11/2019)... ... , ... Advanced Clinical, a clinical research services organization, is ... appointed Therapeutic Lead for Oncology. Dr. Tyan brings a wealth of practical, therapeutic, ... delivery credentials previously offered at Advanced Clinical. , Dr. Tyan has worked extensively ...
(Date:10/10/2019)... ... October 10, 2019 , ... Mindray, a ... attendees of the American Society of Anesthesiologists 2019 Annual Meeting to visit exhibit ... 19-21 in Orlando, Florida, and will provide more than 14,000 healthcare professionals from ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... ... October 02, 2019 , ... Today marked the ... is enabling clinical program outsourcing success by cultivating radical improvements in leadership, staff, ... veteran executive Brenda Reese, phaseUP™ brings clients deep, broad and unique expertise in ...
(Date:10/3/2019)... (PRWEB) , ... October 02, 2019 , ... eKare’s inSight® ... NHS Digital Health Accelerator run by the East Midlands Academic Health Science Network (EMAHSN), ... adoption of technology in NHS by providing support to develop and deploy solutions to ...
(Date:10/3/2019)... ... 2019 , ... Yesterday, at the 2019 meeting of Outsourcing in Clinical Trials ... Sherley, M.D., Ph.D., discussed important design factors that currently limit the success of early ... suppliers of clinical trials, in his talk Dr. Sherley focused on the ...
(Date:9/24/2019)... WEST LAFAYETTE, Ind. (PRWEB) , ... ... ... Pharma LLC will be presenting their latest research in the area of ... Monday, November 4th, Dr. Pamela Smith, COO of Improved Pharma, will present ...
Breaking Biology Technology:
Cached News: