HOME >> BIOLOGY >> NEWS
Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

(PHILADELPHIA) Researchers at Jefferson Medical College and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia and at the Albert Einstein College of Medicine in New York have found evidence suggesting that a mutation in a gene that normally helps block the formation of breast tumors could play a role in the initiation of a major form of breast cancer.

The team, led by cell biologist Michael P. Lisanti, M.D., Ph.D., professor of cancer biology at Jefferson Medical College and Richard Pestell, M.D., Ph.D., director of Jefferson's Kimmel Cancer Center, found that a known mutation in the Caveolin-1 gene is present in approximately 19 percent of all breast cancers that are fed by estrogen so called "estrogen receptor-positive" cells. The group also discovered six new Caveolin-1 mutations associated with estrogen-driven breast cancers. As many as nearly 35 percent of such breast cancers may carry Caveolin-1 mutations, Dr. Lisanti says. Caveolin proteins, which play important roles in cell communication, are also involved in a number of diseases and conditions, such as cancer, atherosclerosis, diabetes, Alzheimer's disease and muscular dystrophy.

The researchers, reporting in June 2006 in the American Journal of Pathology, say their results open up the possibility that Caveolin-1 mutations may be involved in the development of estrogen-positive human breast cancer, which accounts for some 70 percent of all breast cancers. "This is the first demonstration that a specific Caveolin-1 mutation is exclusively connected to being estrogen-receptor positive," says Dr. Lisanti, noting that in tests of breast tumor samples, none of those that were estrogen-receptor negative showed caveolin mutations.

"One-third of estrogen receptor-positive patients actually had caveolin mutations, making it one of the most common mutations in that population," he says. "Usually about 70 percent of all human breast cancers are estrogen recep
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
31-May-2006


Page: 1 2 3

Related biology news :

1. Jefferson scientists patent dramatically improves
2. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
3. Tiny genes may increase cancer susceptibility, Jefferson scientists find
4. Jefferson scientists use gene therapy to reverse heart failure in animals
5. Jefferson researchers discovery may change thinking on how viruses invade the brain
6. Jefferson scientists identify protein key to breast cancer spread, potential new drug target
7. Jefferson scientists find rabies-based vaccine could be effective against HIV
8. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
9. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
10. Jefferson scientists find guardian genes choices crucial to stopping cancer process
11. Jefferson researchers uncover new way nature turns genes on and off

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years ... X-rays revealed severe elbow dysplasia, which caused painful osteoarthritis in the joints. She ... Her parents were heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern ...
(Date:5/31/2019)... ... , ... FileWave, the multi-platform endpoint management solution for apps, ... 13.1. The new version extends FileWave’s mobile device management features on the Android ... Version 13.1 builds on FileWave’s version 13 that was released in early October ...
(Date:5/26/2019)... ... May 24, 2019 , ... Zolgensma (Novartis, AveXis), an AAV-delivered gene ... for clinical use in the United States by the Food and Drug Administration today. ... to treat inherited genetic disorders in the United States and the second-ever approved treatment ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... ... pleased to announce the strategic acquisition of Metabiologics, Inc., a globally recognized leader ... Object exclusive ownership and commercialization rights to a full spectrum of botulinum neurotoxins, ...
(Date:5/22/2019)... ... May 22, 2019 , ... Artemis (formerly Agrilyst), the leading enterprise ... funding round co-led by Astanor Ventures and Talis Capital with ... iSelect Fund . The company has raised $11.75m to date and will use ...
(Date:5/15/2019)... ... , ... Milton Hershey School® has named William Charles Ballough Harding ’78 the ... where he is changing lives by creating solutions to global healthcare challenges through the ... of our founders – Milton and Catherine Hershey – who always hoped for Milton ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ ... The redesigned website aims to improve LDA’s ability to communicate directly with the ...
Breaking Biology Technology:
Cached News: