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Jefferson scientist's patent dramatically improves

(PHILADELPHIA) A basic scientist in the Department of Surgery at Jefferson Medical College and the Kimmel Cancer Center at Jefferson has shared a patent on what may someday be a ubiquitous tool in DNA analysis. The discovery could have a range of applications, from forensics to cloning to bioterrorism.

Jonathan Brody, Ph.D., assistant professor of surgery and colleague Scott Kern, M.D., at Johns Hopkins University in Baltimore, have developed a technique that makes a DNA separation technique called electrophoresis five times faster and less expensive than now is possible. It could save millions of dollars a year, just by speeding up processes, says Dr. Brody.

Most molecular biology-based techniques involve electrophoresis, the main way scientists analyze DNA. But the ingredients involved in the process have been unchanged for 30 years. It turns out that all of the buffers people have been using for 30 years have been the wrong choice, he says, because the standard method is more expensive and takes longer. This solution that we found is literally a better, faster way of doing it.

According to Dr. Brody, the patent hinges on the pairs finding, through trial and error, that the compound lithium boric acid in DNA electrophoresis is the optimal solution for this process. -more-

Faster DNA separation -- 2 In electrophoresis, solutions conduct electric current necessary to separate negatively charged DNA molecules. DNA is put through jellylike gels, and smaller DNA molecules move more quickly than larger ones as the current passes through. The researchers found, after much experimentation, that lithium boric acid would be a better buffer solution for the process than current 30-year-old methods.

A process that normally takes around one and a half, two hours to do can be done in 10 minutes in some instances it can be 10-fold faster, he explains.

A lot of our science is abstract and incremental, he notes
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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
18-Jul-2007


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