HOME >> BIOLOGY >> NEWS
Jefferson scientist's patent dramatically improves

(PHILADELPHIA) A basic scientist in the Department of Surgery at Jefferson Medical College and the Kimmel Cancer Center at Jefferson has shared a patent on what may someday be a ubiquitous tool in DNA analysis. The discovery could have a range of applications, from forensics to cloning to bioterrorism.

Jonathan Brody, Ph.D., assistant professor of surgery and colleague Scott Kern, M.D., at Johns Hopkins University in Baltimore, have developed a technique that makes a DNA separation technique called electrophoresis five times faster and less expensive than now is possible. It could save millions of dollars a year, just by speeding up processes, says Dr. Brody.

Most molecular biology-based techniques involve electrophoresis, the main way scientists analyze DNA. But the ingredients involved in the process have been unchanged for 30 years. It turns out that all of the buffers people have been using for 30 years have been the wrong choice, he says, because the standard method is more expensive and takes longer. This solution that we found is literally a better, faster way of doing it.

According to Dr. Brody, the patent hinges on the pairs finding, through trial and error, that the compound lithium boric acid in DNA electrophoresis is the optimal solution for this process. -more-

Faster DNA separation -- 2 In electrophoresis, solutions conduct electric current necessary to separate negatively charged DNA molecules. DNA is put through jellylike gels, and smaller DNA molecules move more quickly than larger ones as the current passes through. The researchers found, after much experimentation, that lithium boric acid would be a better buffer solution for the process than current 30-year-old methods.

A process that normally takes around one and a half, two hours to do can be done in 10 minutes in some instances it can be 10-fold faster, he explains.

A lot of our science is abstract and incremental, he notes
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
18-Jul-2007


Page: 1 2

Related biology news :

1. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
2. Tiny genes may increase cancer susceptibility, Jefferson scientists find
3. Jefferson scientists use gene therapy to reverse heart failure in animals
4. Jefferson researchers discovery may change thinking on how viruses invade the brain
5. Jefferson scientists identify protein key to breast cancer spread, potential new drug target
6. Jefferson scientists find rabies-based vaccine could be effective against HIV
7. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
8. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
9. Jefferson scientists find guardian genes choices crucial to stopping cancer process
10. Jefferson researchers uncover new way nature turns genes on and off
11. Jefferson researchers develop combined procedure for uterine preservation in treating fibroids

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 18, 2019 , ... Flagship Biosciences, the advanced ... to its executive team as Vice President of Operations. Ms. James brings a ... new role, Ms. James is responsible for ensuring on-time delivery of all projects ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... acclaimed pediatric urologists are among the professionals honored in U.S. News & ... among the country’s pediatric healthcare landscape. , Georgia Urology’s wholly-owned subsidiary, ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... Mytonomy, the leader ... leader in opioid treatment, announced today they are partnering to combat the opioid ... deployed its virtual care platform at the Mayo Clinic to drive shared decision ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... 29, 2019 , ... For many years, the primary forms of cancer treatment ... therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T ... cell receptors known as “CARs”. The CAR enables the final product to produce chemicals ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... thinking on Data Integrity on July 08-09, 2019 in Boston, MA. This peer ... and medical device organizations. , The training will kick off with a compendial ...
Breaking Biology Technology:
Cached News: