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Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer

own as the molecular motor in the mitochondria, and responsible for the production of ATP and energy in cells, says Dr. Buchberg. They have dubbed Atp5a1 Mom2, for Modifier of Min 2 gene, having previously identified the first modifier of Min mice, Mom1.

No one as far as we know has ever found a mutation in this gene, says Dr. Siracusa, noting that both gene mutations Apc and Atp5a1 are on mouse chromosome 18. If the other normal chromosome is lost for some reason, or mice have two copies of the mutant Atp5a1, they die in embryonic development, presumably because the cells lack an energy source.

The corresponding human gene, ATP5A1, is also located on chromosome 18, in a region that sometimes shows genetic mutations in colon tumors.


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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
21-Mar-2007


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