HOME >> BIOLOGY >> NEWS
Jonathan Baell wins Biota Award for Medicinal Chemistry

An innovative paper published in the Journal of Medicinal Chemistry has earned Dr Jonathan Baell a significant award from the Royal Australian Chemical Institute.

The amplification of some unusual qualities of a naturally-occurring substance, Khellinone, derived from a Chilean plant, raises the prospect of developing a compound to prevent the destructive autoimmune impact of the body's own T cells upon myelin proteins.

Myelin is the substance that, in effect, provides the insulation to the body's electrical wiring. The mistaken destruction of this insulation by the body's immune system is a major contributor to the development of multiple sclerosis (MS).

The natural anti-inflammatory effect of Khellinone is detectable but also quite weak certainly far too weak in its natural state to prevent myelin destruction. Dr Baell and his collaborators in Australia and overseas have determined that it is possible to increase the potency of this substance, which acts to disrupt the potassium channels of the body's rogue T cells, thereby reducing their capacity to cause damage to the body.

Dr Baell, who heads the discovery team in the Medicinal Chemistry Group in WEHI's Structural Biology Division, says that the next step is to determine efficacy (or effectiveness) in the animal model. He adds, "Our ultimate objective is to reduce the incidence of MS in humans, certainly as far as rogue T cell action is concerned. Our way of doing this is not to repress the action of the entire immune system, which is what most current drugs tend to do. We have determined that the T cells causing the problems for MS patients are quite distinct in their chemical composition. Aiming new compounds at these distinct cells may well be a selective and productive way of tackling MS."

Reflecting on the award, Dr Baell added, "The Biota award will, I hope, raise the profile of early phase medicinal chemistry and emphasise its fundamental role in drug discovery
'"/>

Contact: Brad Allen
61-3-9345-2345
Research Australia
28-Jul-2005


Page: 1 2

Related biology news :

1. Awards celebrating women and biotech brilliance
2. Serica scientists win AOSSM Award for ACL (knee) tissue regeneration in preclinical study
3. ASM scores a hat-trick at the 2007 Hermes Creative Awards
4. Developer of new method for treating bone defects wins WPI Entrepreneurship Award
5. Ossurs PROPRIO FOOT takes the Gold 2007 Medical Design Excellence Award
6. Michael R. Zalutsky receives SNMs 2007 Paul C. Aebersold Award
7. SNM recognizes R. Edward Coleman with 2007 Georg Charles de Hevesy Nuclear Pioneer Award
8. Scientists honored with Excellence in Clinical Research Award
9. 2007 Alzheimer Award to Jing Zhang, M.D., Ph.D.
10. Weill Cornell pharmacologist receives prestigious NIH MERIT Award
11. JDRF announces 2007 Scholar Award recipients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... , ... August 20, 2019 , ... ... and commercialization of bioactive technologies for the spine, today announced the 510(K) clearance ... a unique surface modification that is proven to improve osseointegration through superior hydrophilicity ...
(Date:8/15/2019)... TORONTO (PRWEB) , ... August 15, 2019 , ... ... finally passed. Now what? As serialization mandates become increasingly complex, and aggregation becomes ... their current serialization software is the best long-term solution. , Until now, most ...
(Date:8/14/2019)... ... ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, BioTel Research ... EDT to learn about two common imaging methods in NAFLD/NASH to aid with early ... diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can be subdivided ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... , ... September 16, 2019 , ... ... via CNBC on Saturday, September 21st @11:00am ET. Check local listings for more ... Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to developing ...
(Date:9/11/2019)... ... September 10, 2019 , ... Catalent, the leading global provider ... and consumer health products, today announced that Alex Haig, Senior Director, Engineering will ... AG, Schwabisch Hall, Germany, on Sept. 18-19, 2019. , On Wednesday, Sept. 18 ...
(Date:9/2/2019)... , ... September 02, 2019 , ... ... and in vitro diagnostics, has launched the industry’s first epigenetics data mining services ... meaning of epigenetic data and other data types. , Next generation sequencing in ...
(Date:8/27/2019)... HOUSTON (PRWEB) , ... August 27, 2019 , ... ... chain engineering firm, is pleased to announce it has promoted Consulting Engineer, Robert ... Solutions, Battista has added the responsibility of onboarding and mentoring new engineers as ...
Breaking Biology Technology:
Cached News: