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Joslin-chaired study shows new compound may decrease vision loss in diabetes

od glucose associated with diabetes). In diabetic animal models, the lab also showed that abnormal activation of PKC is an important factor in decreasing blood flow to the retina. These seminal discoveries established the link between hyperglycemia, PKC and diabetic eye disease.

Having established this link, Dr. King began working with scientists at Eli Lilly to design a chemical inhibitor for the PKC-beta isoform. It was from this collaboration that RBX emerged.

Drs. King and Aiello also collaborated on a number of PKC retinal studies that provided further evidence of the link between PKC and blood vessel abnormalities of the eye, conditions which improved following treatment with the PKC-beta inhibitor.


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14-Jul-2005


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