HOME >> BIOLOGY >> NEWS
Joslin study refutes recent report that bone marrow can replenish female oocytes

Ovulated egg cells, or oocytes, in adult female mice are not formed from germ cells in the blood or bone marrow. That's the conclusion of a new study led by investigators at Joslin Diabetes Center and Harvard University. These findings refute a controversial recent study conducted at Massachusetts General Hospital (MGH), which itself contradicted the long-held belief that female mammals are born with a finite number of oocytes that cannot be replenished or regenerated if lost to injury or disease by suggesting that transplanted bone marrow or peripheral blood cells were capable of generating new oocytes in the ovaries of recipient mice.

The Joslin study will appear in an upcoming issue of Nature and on the journal's Web site on June 14, 2006.

"It was a very important study to do," says Amy J. Wagers, Ph.D., Investigator in Developmental and Stem Cell Biology at Joslin Diabetes Center and Assistant Professor of Pathology at Harvard Medical School. "The suggestion that bone marrow cells might represent a previously unappreciated source of cells capable of restoring female fertility had significant implications for patients undergoing chemotherapy, which often leads to sterility, and for individuals donating or receiving bone marrow cells for transplant, as well as for women experiencing premature menopause."

The MGH study reported that transplanted cells from the bone marrow or blood could enter the ovaries of genetically infertile or chemically sterilized female mice and produce new oocytes but didn't study whether those oocytes could be ovulated, or whether bone marrow cells normally migrate to the ovary as part of a normal process of ovary regeneration. The Joslin study's goal was to find out if that was possible.

Joslin study researchers used a parabiotic mouse model in which pairs of mice are joined using a surgical procedure that enables blood vessels to fuse such that the mice develop a common circulatory system. "It's a very u
'"/>

Contact: Jenny Eriksen
jenny.eriksen@joslin.harvard.edu
617-732-2415
Joslin Diabetes Center
14-Jun-2006


Page: 1 2 3

Related biology news :

1. Joslin study indicates insulin receptors play a critical role in promoting islet growth
2. Joslin researchers discover a surprising culprit in the search for causes of diabetic birth defects
3. Joslin study reveals how a specific fat type can protect against weight gain and diabetes
4. Joslin discovers protein that causes blood vessel leakage and swelling with diabetic retinopathy
5. Joslin-led study uncovers role of appetite hormone MCH in insulin production
6. Joslin Diabetes Center study examines insulin pump therapy in adolescents
7. Joslin Diabetes Center in Boston establishes first affiliate in Canada
8. Walgreens and Joslin Diabetes Center form broad alliance to improve diabetes outcomes
9. Joslin awards Victory Medal to New York man living 75 years with type 1 diabetes
10. Joslins new book demystifies nutrition and meal planning for people with diabetes
11. Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/18/2017)... Calif. , April 18, 2017  Socionext Inc., a global ... of a media edge server, the M820, which features the company,s ... recognition software provided by Tera Probe, Inc., will be showcased during ... at the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
Breaking Biology Technology:
Cached News: