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Joslin study reveals how a specific fat type can protect against weight gain and diabetes

lucose intolerance. In the new study, Dr. Kahn and his colleagues showed that this difference is due to the higher basal energy expenditure in the 129 mouse. When searching for the source of the energy expenditure, the researchers found unexpected clusters of brown fat cells stuck between bundles of muscle fibers in the leg of the mouse. In this case, the 129 mouse had over 100 times more brown fat in muscle than the B6 mouse.

This site of brown fat was previously unrecognized and is certainly one of the reasons for the differences in energy expenditure between strains of mice. Now we need to see if the same is true for humans and if this could account for why some people gain weight easily and others seem to be protected against weight gain and metabolic syndrome that can lead to type 2 diabetes, Dr. Kahn said. Finding drugs that stimulate the amount or activity of this brown fat could also lead to a new therapy for obesity and prevention of diabetes.


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Contact: Marjorie Dwyer
marjorie.dwyer@joslin.harvard.edu
617-732-2415
Joslin Diabetes Center
1-Mar-2007


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11. Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

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