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Keck Futures Initiative announces grant recipients

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DEBRA WEINER and CARLO BRUGNARA, Harvard Medical School, Boston
ROLE OF NITRIC OXIDE ON WHITE BLOOD CELL FUNCTION IN INFLAMMATION AND INFECTION - $75,000
These researchers will use state-of-the-art microscale technology to measure and compare cellular events and white blood cell genomic expression in IN VITRO human models of infection and inflammation. Nitric oxide is an important mediator of white blood cell function in the pathogenesis and host defense of infectious and inflammatory processes.

BABAK PARVIZ, University of Washington, Seattle
DIRECT ELECTRONIC DETECTION OF MOLECULAR RECOGNITION AND BINDING EVENTS WITH ENGINEERED NANO-SCALE STRUCTURES - $75,000
Two nano-scale sensing mechanisms based on tunneling current and surface dipole fields will be investigated for direct conversion of molecular recognition and binding events to electronic signals. The new sensing mechanisms will provide powerful tools for furthering the understanding of biology at the small scale and extending the link between the genomic information and phenotype and the eventual disease.

CHRISTOPHER PLOWE and SHANNON TAKALA, University of Maryland School of Medicine, Baltimore
GENETIC DIVERSITY AND EFFICACY OF MALARIA DRUGS AND VACCINES - $75,000
These researchers will develop new genomic tools to assess how genetic differences in malaria parasites affect the ability of drugs to treat malaria and the ability of vaccines to prevent the disease in clinical trials in Africa.

DAVID RELMAN, Stanford University, Stanford, Calif.
ANNE RIMOIN, University of California, Los Angeles
BRINGING GENOMICS TO THE RAINFOREST: THE STUDY OF MONKEYPOX IN THE DEMOCRATIC REPUBLIC OF CONGO - $75,000
Monkeypox is an emerging infectious disease in Africa, and it unexpectedly caused an outbreak in the United States in 2003. These researchers will study the responses of patients with monkeypox in the Democratic Republic of
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Contact: Maureen O'Leary
news@nas.edu
202-334-2138
The National Academies
10-Apr-2006


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