HOME >> BIOLOGY >> NEWS
Keeping amyloid - and Alzheimer's - in check

Researchers have identified a protein that reins in the rogue activity of the molecules that make the amyloid-beta protein--which may prevent normal brain function in people with Alzheimer's disease. Their findings reveal a potentially powerful tool for designing novel Alzheimer's treatments.

Amyloid beta-peptides are sticky, neurotoxic protein fragments that accumulate, kill nerve cells, and clump together to form the distinctive amyloid plaques in the brains of people with Alzheimer's disease. They are generated when a larger, normal protein called amyloid precursor protein (APP) is cleaved or split in a series of events. A protein complex called the presenilin complex is responsible for the final cleavage event.

Presenilin complexes are thought to cause an unusual form of protein cleavage in which selected membrane proteins are split in a region that crosses cell membranes. This previously unrecognized form of protein cleavage is essential for several normal signaling processes.

The same presenilin complex also generates amyloid-beta from APP. The presenilin cleavage that generates amyloid-beta may be a physiological process unrelated to signaling. In fact, it may just be a way to remove unneeded protein stubs from cellular membranes.

However, new findings from Howard Hughes Medical Institute (HHMI) international research scholar Peter St George-Hyslop at the University of Toronto argue against this hypothesis. St George-Hyslop's group recently pinpointed a new component called TMP21 that controls presenilin's dicing tendencies, preventing it from snipping apart APP. The researchers report their findings in the April 27, 2006, issue of the journal Nature.

When TMP21 was first discovered, it appeared to be a "cargo transporter" that embeds itself in the membranes of transport vesicles--small, bladder-like sacs that shuttle proteins from one cellular locale to another. St George-Hyslop's group discovered that TMP21 moo
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
26-Apr-2006


Page: 1 2 3

Related biology news :

1. Keeping the immune system from starting a food fight
2. Keeping the body in sync -- the stability of cellular clocks
3. Keeping cool in a war zone: Device promises relief for desert soldiers
4. Keeping biological tubes in check: New insights into tube size morphogenesis
5. Keeping cancer in check
6. Stem cell procedure successfully treats amyloidosis patients
7. What causes Alzheimers? Researchers tie beta-amyloids to brain dysfunction
8. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
9. Can senile amyloidosis spread from mother to offspring?
10. The unfolding of amyloids true colors
11. Impaired clearance of amyloid-beta causes vascular damage in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... August 06, 2019 , ... ... concerns. One plant-based food in particular quickly entered the limelight – meat alternatives. ... use a thermogelling and emulsifying ingredient such as methyl cellulose. This ingredient is ...
(Date:8/1/2019)... , ... August 01, 2019 , ... The GENSPEED platform ... of care. It is fully developed with over 100 units deployed in the ... new fields of use, our collaboration with axiVEND will give us a foothold in ...
(Date:8/1/2019)... ... July 31, 2019 , ... Molecular Devices, LLC, a leader ... generation of its FLIPR® Penta High-Throughput Cellular Screening System. , The new FLIPR ... of G-protein-coupled receptors (GPCRs) and ion channels, offering a new high-speed camera option ...
Breaking Biology News(10 mins):
(Date:7/26/2019)... ... July 25, 2019 , ... ... collaboration and dialogue, today announces its Boston BD conference to be ... of Biotech Week Boston , the event provides an opportunity for attendees ...
(Date:7/17/2019)... ... July 16, 2019 , ... ... and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis gene therapy treatment for ... will have dedicated manufacturing space at the new, state-of-the-art commercial manufacturing center ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma ... Biotech. The film focuses on regenerative veterinary medicine as a means of improving ... recently included in the Brentwood and Pacific Palisades International Film Festival in Los ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... network with the appointment of Biofeedback Tech Ltd as its authorised ... an essential part of many therapeutic treatments and clinical assessment protocols to treat ...
Breaking Biology Technology:
Cached News: