Keeping the body in sync -- the stability of cellular clocks

of the cellular clocks. Stability is a measure of how fast the system reverts to its initial state after being perturbed.

To my knowledge we are the first to discuss how the stability of the oscillator directly affects bioluminescence recordings, explains Felix Naef, a systems biology professor at EPFL and the Swiss Institute for Experimental Cancer Research. We found that the phosphorylation and transcription rates of a specific gene are key determinants of the stability of our internal body clocks.

This result is consistent with recent research from the University of California, San Francisco involving families whose circadian clocks dont tick quite right. These families clocks are shorter than 24 hours, and they also have mutations in oscillator-related genes. The current results shed light on how a genetically-linked phosphorylation event gone wrong could lead to inaccurate timing of our body clockworks.


Contact: Felix Naef
Ecole Polytechnique Fdrale de Lausanne

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