HOME >> BIOLOGY >> NEWS
Keeping the immune system from starting a 'food fight'

After every meal, the body must prevent the immune system from launching an all-out fight against food. Now, researchers report the identity of a nutrient "floodgate" that serves to protect against such an inflammatory immune response. Their findings appear in the May 4, 2007 issue of the journal Cell, a publication of Cell Press.

The researchers found that animals lacking a protein enriched in fat cells, called STAMP2, develop acute inflammation in deep pockets of visceral fat. The animals also showed symptoms of metabolic syndromeincluding insulin resistance and fatty liver diseaseeven while eating a regular diet.

In those who regularly consume an overload of nutrients, the flood control protein may become overwhelmed and give out, leading to the chronic, low-grade inflammation characteristic of obesity and other metabolic diseases, the researchers suggest. Treatments designed to reinforce that barrier may therefore provide the "next frontier" of therapies to combat the rising tide of chronic metabolic disease, they said.

"Humans were not meant to deal with little to no exercise and a constant bombardment of nutrients," said Gkhan Hotamisligil of the Harvard School of Public Health of his teams findings. "If we could find ways to strengthen STAMP2 or prevent its suppression, the body might retain control," effectively unlinking chronic overeating and obesity from other symptoms of metabolic disease. He cautioned, however, that the realization of such a treatment strategy remains uncertain and would require years of continued investigation.

Cells and organisms must strike an appropriate balance between nutrient sufficiency and surplus, the researchers explained. While adequate amounts of nutrients must be obtained to ensure health and survival, chronic overeating can lead to obesity and an array of associated metabolic disorders, including insulin resistance, fatty liver disease, type 2 diabetes, and cardiovascular disease
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
3-May-2007


Page: 1 2

Related biology news :

1. Keeping the body in sync -- the stability of cellular clocks
2. Keeping cool in a war zone: Device promises relief for desert soldiers
3. Keeping amyloid - and Alzheimers - in check
4. Keeping biological tubes in check: New insights into tube size morphogenesis
5. Keeping cancer in check
6. Bursts of waves drive immune system soldiers toward invaders
7. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
8. A stepwise retreat: How immune cells catch pathogens
9. Link between immune system and mammary gland could shed new light on breast cancer
10. Researchers discover method for identifying how cancer evades the immune system
11. Invertebrate immune systems are anything but simple, conference finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... Dutch ... the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for SARS-CoV-2 ... The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of SARS-CoV-2," ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... R&D, today announced that it has entered into a multi-year contract with ... to support their translational and clinical research strategy to discover and develop ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that the company has received ISO9001:2015 certification for the development ... research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 30, 2020 , ... ... launch of a new clinical diagnostics immuno-oncology service, TissueInsight . TissueInsight ... , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and immunologists ...
(Date:6/28/2020)... Calif. (PRWEB) , ... June 25, 2020 , ... ... researchers are racing to develop a vaccine or drug treatment. In an effort ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic compound ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security ... announced its strong opposition to the recently introduced bicameral Facial Recognition and ... on most federal use of nearly all biometric and related image analytics technologies, ...
(Date:6/23/2020)... ... 2020 , ... DeCurtis Corporation, the premier provider of location ... has been appointed CEO and President. Founder and former CEO, David DeCurtis, will ... Corporation has been on an incredible journey for the last twenty years, and ...
Breaking Biology Technology:
Cached News: