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Key fat and cholesterol cell regulator identified, promising target

rdles that would need to be overcome before finding specific and effective treatments based on these findings," says Dr. Nr. If small molecules that specifically interfere with the interaction of SREBPs and ARC105 could be identified, careful studies in human cells and in mice would be needed to verify the specificity and efficacy in repressing cholesterol and fat production. "Unforeseen side effects of such small molecules in mouse studies or in human clinical trials could also emerge, prohibiting further follow-up", cautions Dr. Nr.


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Contact: John Lacey
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
2-Aug-2006


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