HOME >> BIOLOGY >> NEWS
Key to acute lung injury lies in Ang2 protein

Acute lung injury caused by cell death, high and potentially toxic concentrations of oxygen (hyperoxia), and the resulting excess fluid in the lungs (pulmonary edema), may be controlled by modulating levels of the angiopoietin2 (Ang2) protein, researchers at Yale School of Medicine report in the November 5 online issue of Nature Medicine.

The study, which was completed in the laboratory of senior author Jack Elias, M.D., the Waldemar Von Zedtwitz Professor and chair of internal medicine at Yale, looked at the response to hyperoxic acute lung injury (HALI), first in mice and then in human adults and babies. The team found that mice in which the Ang2 gene was genetically eliminated or silenced lived longer and had evidence of decreased lung injury compared to mice in which the gene and protein were intact.

Levels of the Ang2 protein were then measured in the blood and lung fluid of adult patients and babies with acute lung damage and pulmonary edema. The team found that levels of Ang2, which is known to increase leaks in blood vessels and causes the death of endothelial cells that line the blood vessels, were higher in adult patients with acute lung injury and in babies born with respiratory distress syndrome who either went on to develop bronchopulmonary dysplasia or died.

"Mice without Ang2 seemed to be protected against hyperoxia," said first author Vineet Bhandari, M.D., assistant professor of pediatrics at Yale School of Medicine. "This protein seems to be a mediator of cell death in the settings of high oxygen concentrations in the lung causing acute lung injury and pulmonary edema."

Bhandari said the study is an example of true bench-to-bedside translational research. "All the work was initially done on mice in which we found that the Ang2 protein was involved in HALI," said Bhandari. "We also defined how the protein creates lung injury and then we showed its clinical relevance by documenting its presence in human pati
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
10-Nov-2006


Page: 1 2

Related biology news :

1. Investigating antibiotic use in acute care patients
2. Scientists gain important insights into acute promyelocytic leukemia
3. Scientists identify new strategy for preventing acute and chronic brain disease
4. The metabolic response to colitis varies depending upon whether inflammation is chronic or acute
5. NIH study finds MRI more sensitive than CT in diagnosing most common form of acute stroke
6. Researchers identify cells that make relapse inevitable in acute lymphoblastic leukemia
7. Progress in battle against life-threatening acute allergy
8. In túngara frogs, female choice for complex calls led to evolution of unusual male vocal cord
9. South African geraniums effective in treatment of adults with acute bronchitis
10. A persistent immune response to an acute viral infection
11. Childrens Hospital of Pittsburgh to lead international study of acute liver failure in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... ... May 07, 2019 , ... ... been accepted into Forbes Technology Council, an invitation-only community for world-class CIOs, ... is a full-service biopharmaceutical cold chain engineering firm that guarantees confidence in ...
(Date:5/7/2019)... LONDON (PRWEB) , ... May 07, 2019 , ... ... the world’s first on-site Legionella DNA test in the UK. , In May, ... accurate qPCR Legionella results in 45 minutes, enabling operators to take corrective action ...
(Date:5/2/2019)... ... May 01, 2019 , ... uBiome, ... appointed John Rakow, the Company’s General Counsel, as Interim Chief Executive Officer of ... are currently on administrative leave. There will also be an independent investigation into ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, ... (DF). Urandir detailed the results of some research carried out by the association, ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current ... and food industries. Access to all webinars is free, so be sure to register ... field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS ...
(Date:4/25/2019)... FRANCISCO (PRWEB) , ... April 24, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced global availability ... center software providers and enterprises of all sizes to harness the power of ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., ... $2 million bench plant expansion to increase production of methylene malonate monomers and ... and construction of Sirrus’ full-scale production facility, which is scheduled to break ground ...
Breaking Biology Technology:
Cached News: