HOME >> BIOLOGY >> NEWS
'Killer' B cells provide new link in the evolution of immunity

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered a unique evolutionary link between the most primitive innate form of immune defense, which has survived in fish, to the more advanced, adaptive immune response present in humans and other mammals.

The finding, which appears in the online version of the October issue of Nature Immunology, represents an evolutionary step for the mammalian immune system and offers a potential new strategy for developing much-needed fish vaccines.

In the adaptive immune system in mammals, B cells produce antibodies to fight infection. In the more-primitive innate immunity in fish, the scientists found that B cells take part in a process known as phagocytosis, by which immune system cells ingest foreign particles and microbes.

In modern mammals, the B cell is a highly adapted part of the immune system chiefly responsible for, among other things, the creation of antibodies that tag foreign particles and microbes for destruction.

"When examining fish B cells we see them actively attacking and eating foreign bodies, which is a behavior that, according to the current dogma, just shouldn't happen in B cells," said J. Oriol Sunyer, a professor in Penn Vet's Department of Pathobiology and leader of the research team.

The researchers determined that these attack B cells account for more than 30-40 percent of all immune cells in fish, whereas phagocytic cells make up only a small portion of the total number of immune cells in mammals.

According to Sunyer, the findings are important for not only understanding the evolution and function of immune cells in fish but also may point to novel roles of B cells in mammals. Their findings also have an agricultural implication. Vaccines currently given to farmed salmon, for example, appeal to the fish's adaptive immune response, which this research now shows to be a small part of the overall fish immune
'"/>

Contact: Leslie Fink
lfink@nsf.gov
703-292-5395
National Science Foundation
3-Oct-2006


Page: 1 2

Related biology news :

1. Killer B cells demonstrate evolutionary link between fish and mammal immune systems
2. Newly created cancer stem cells could aid breast cancer research
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. OHSU turns mouse into factory for human liver cells
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. UCF research links proteins, stem cells and potential Alzheimers treatment
7. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. How cells change the pace of their steps
10. Discredited Korean embryonic stem cells true origins revealed
11. A low expression of MX2 gene exists in the white blood cells of narcoleptics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Killer cells provide new link the evolution immunity

(Date:4/17/2014)... NY, April 17, 2014The development of stem cell therapies ... ability to characterize stem cell populations based on cell ... discovered a new marker that is highly expressed in ... cord blood, which they describe in an article in ... Mary Ann Liebert, Inc., publishers. The article is available ...
(Date:4/17/2014)... Andr Gauthier and Professor Luca Razzari of the ... awarded large grants from the John R. Evans ... (CFI) for the acquisition of state-of-the-art biotech and ... matching grants from the Ministre de l,Enseignement suprieur, ... la Technologie (MESRST). These new laboratories will help ...
(Date:4/17/2014)... is available in German . ... recognise objects; they also provide us with a continuous stream ... around, fall or sit still in a car the ... on our retinas. Seemingly without effort, our brain calculates self-motion ... stable position and a steady gaze during our own movements. ...
Breaking Biology News(10 mins):New state-of-the-art biotech and nanotech equipment for INRS 2How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4
(Date:1/15/2014)... , January 15, 2014 A study ... races on the Formula 1 track could help to tackle ... Applied Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... healthcare provider Simplyhealth. Telemetry technology, which is inspired ...
(Date:1/15/2014)... Two champions of science, technology, engineering, ... an annual competition for middle and high school students ... STEM study. The competition presents students with real-world problems ... Aptitude, Mathematics, and Sciences is a program administered ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to announce ... organizations who need document translations. Clients will now have ... in advance with a selection of nearly 50 life science ... critical factor in clinical and scientific fields, and decrease the ...
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
Cached News: