HOME >> BIOLOGY >> NEWS
'Killer' B cells provide new link in the evolution of immunity

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered a unique evolutionary link between the most primitive innate form of immune defense, which has survived in fish, to the more advanced, adaptive immune response present in humans and other mammals.

The finding, which appears in the online version of the October issue of Nature Immunology, represents an evolutionary step for the mammalian immune system and offers a potential new strategy for developing much-needed fish vaccines.

In the adaptive immune system in mammals, B cells produce antibodies to fight infection. In the more-primitive innate immunity in fish, the scientists found that B cells take part in a process known as phagocytosis, by which immune system cells ingest foreign particles and microbes.

In modern mammals, the B cell is a highly adapted part of the immune system chiefly responsible for, among other things, the creation of antibodies that tag foreign particles and microbes for destruction.

"When examining fish B cells we see them actively attacking and eating foreign bodies, which is a behavior that, according to the current dogma, just shouldn't happen in B cells," said J. Oriol Sunyer, a professor in Penn Vet's Department of Pathobiology and leader of the research team.

The researchers determined that these attack B cells account for more than 30-40 percent of all immune cells in fish, whereas phagocytic cells make up only a small portion of the total number of immune cells in mammals.

According to Sunyer, the findings are important for not only understanding the evolution and function of immune cells in fish but also may point to novel roles of B cells in mammals. Their findings also have an agricultural implication. Vaccines currently given to farmed salmon, for example, appeal to the fish's adaptive immune response, which this research now shows to be a small part of the overall fish immune
'"/>

Contact: Leslie Fink
lfink@nsf.gov
703-292-5395
National Science Foundation
3-Oct-2006


Page: 1 2

Related biology news :

1. Killer B cells demonstrate evolutionary link between fish and mammal immune systems
2. Newly created cancer stem cells could aid breast cancer research
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. OHSU turns mouse into factory for human liver cells
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. UCF research links proteins, stem cells and potential Alzheimers treatment
7. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. How cells change the pace of their steps
10. Discredited Korean embryonic stem cells true origins revealed
11. A low expression of MX2 gene exists in the white blood cells of narcoleptics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Killer cells provide new link the evolution immunity

(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
(Date:10/14/2014)... of scientists led by researchers at the University ... of Miami Miller School of Medicine (UMMSM) have ... underlying bipolar (manic depressive) disorder, a breakthrough that ... affective disorder, as well as depression and other ... online this week in Nature Molecular Psychiatry ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Bromine ... in Asia-Pacific with analysis and forecast of revenue. ... Pacific Bromine Market report, to get an idea ... a glimpse of the segmentation in the Asia-Pacific ... and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The report ... Market Share, Trade, Prices, Geography Trend and Forecast (2011 ... sales category, and geography and studies the major market ... North America, Europe, and Asia. , The global chocolate ... 2010.to $98.3 billion in 2016 at an estimated CAGR ...
(Date:10/19/2014)... According to market research report “Outdoor Wi-Fi ... gateways)]- Global Advancements, Forecasts and Analysis (2013 - ... market with analysis and forecasting of the global ... drivers and the restrains for this market with ... , Browse 65 market data tables and 69 ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... - Trends and Forecasts to 2019", analyzes the ... in order to understand the industry details such ... opportunities across various geographic regions. , Browse 81 ... 202 Slides and in-depth TOC on “1,6-Hexanediol Market ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
Cached News: