HOME >> BIOLOGY >> NEWS
Knocking out survival protein could aid leukemia treatment

COLUMBUS , Ohio -- An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows.

The findings suggest that a drug that can block this "survival protein" might on its own be an effective therapy.

But such a drug used in combination with several existing drugs might also offer an effective one-two punch against drug-resistant forms of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). The two forms of cancer kill about 20,500 Americans yearly.

The survival protein is called Mcl1. It usually helps keep normal cells healthy and is involved in the development of the components of the immune system, but it can also help prolong survival of cancer cells.

Cells with an overabundance of the protein are also more resistant to anticancer drugs such as rituximab, which has revolutionized the treatment of certain chronic and acute leukemias.

The study by researchers at the Ohio State University Comprehensive Cancer Center is published online in the journal Clinical Cancer Research.

"Our findings demonstrate that Mcl1 may be an effective target for drugs directed against CLL and ALL," says principal investigator John C. Byrd, professor of internal medicine and director of the hematologic malignancies program at Ohio State's James Cancer Hospital and Solove Research Institute.

"These results give us a rationale for lowering the amount of this protein in CLL cells and suggest that this should enhance the action of rituximab and perhaps other agents as well."

Rituximab is an antibody-based drug that targets CLL and ALL cells and causes the cells to self-destruct.

"We've shown that knocking down Mcl1 can, by itself, cause CLL cells to die, and that this effect might enhance the activity of rituximab," says first author Rehan Hussain, a postdoctoral fellow with Ohio State's Comprehensive Ca
'"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
20-Apr-2007


Page: 1 2

Related biology news :

1. New use for a cell toxin found to inhibit survival proteins in cancer cells
2. Glimmer of hope for Tahitian tree snails survival
3. Nexavar significantly extends overall survival by 44 percent in liver cancer patients
4. For many insects, winter survival is in the genes
5. HIV survival improves if patients stay in care
6. Preterm infants with RDS -- surfactant replacement therapies improves neonatal survival
7. Pancreatic cancer markers identified, may predict survival
8. Salk scientists hammer out a pathway that promotes muscle cell survival in mice
9. Cetuximab and irinotecan combination increases survival in metastatic colorectal cancer
10. Cetuximab increases survival in advanced colorectal cancer patients, study shows
11. Experience affects new neuron survival in adult brain; study sheds light on learning, memory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/14/2016)... -- NXTD ) ("NXT-ID" or the "Company"), a ... airing of a new series of commercials on Time Warner ... st .  The commercials will air on Bloomberg TV, Fox ... Street show. --> NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ...
(Date:3/11/2016)... , March 11, 2016 ... new market research report "Image Recognition Market by Technology ... (Marketing and Advertising), by Deployment Type (On-Premises and Cloud), ... To 2022", published by MarketsandMarkets, the global market is ... to USD 29.98 Billion by 2020, at a CAGR ...
(Date:3/9/2016)... March 9, 2016 This BCC Research report ... of the RNA Sequencing (RNA Seq) market for the ... instruments, tools and reagents, data analysis, and services. ... of the RNA-Sequencing market such as RNA-Sequencing tools and ... main factors affecting each segment and forecast their market ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific (KinderScientific.com), a leading ... position the Company for the future. Kinder Scientific announces restructured ownership and ... been appointed Chairman of the Board, Curtis D. Kinghorn has been appointed CEO/President ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... of fracture-specific plating options designed to address fractures of the distal tibia and ... , The Acumed Ankle Plating System 3 is composed of seven plate families ...
(Date:5/25/2016)... UTAH. (PRWEB) , ... May 25, 2016 , ... WEDI, ... healthcare information exchange, today announced that Charles W. Stellar has been named by the ... interim CEO since January 2016. As an executive leader with more than 35 years ...
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
Breaking Biology Technology:
Cached News: