HOME >> BIOLOGY >> NEWS
Knockout Mouse Project

Oakland, CA (September 7, 2006) - Children's Hospital & Research Center Oakland is leading one of two teams in an international effort to produce thousands of genetically altered mice for a study to understand the role of individual genes in human health. Other members of the team represent the School of Veterinary Science at the University of California, Davis and the Wellcome Trust Sanger Institute in Hinxton, England. The National Institutes of Health (NIH), announced the selection of the hospital's research institute for the Knockout Mouse Project (KOMP) on September 7, 2006.

The $50 million initiative funded by the NIH is intended to help researchers explore the functions of 10,000 mouse genes. Humans and mice share the same characteristics for most of the 10,000 mouse genes identified for this study. Researchers hope to catalogue and confirm the functions of these genes and identify the disease consequences if these genes are defective. Since human and mice genes are similar, it is hoped that by inactivating mouse genes, one-by-one, the altered mice will yield clues about the function of human genes and their similar roles in human diseases.

"The process is a long one, but the rewards are immeasurable," said Pieter de Jong, Ph.D., Children's Hospital Oakland Research Institute scientist and principle investigator for KOMP. "We're at the forefront of understanding the pathology of human genes. By knocking out each gene one-by-one, we will be able to create a central resource for researchers and scientists to use and study," said Dr. de Jong.

Children's Hospital Oakland Research Institute has a recombinant DNA library with more than 30 million DNA samples that are used in research programs around the world. The research institute's DNA library has become a major resource for ongoing global research in the genetics of human diseases. The recombinant DNA library is, for example, being used in Oakland to investigate the geneti
'"/>

Contact: Diana Yee
dyee@mail.cho.org
510-428-3120
Children's Hospital & Research Center at Oakland
7-Sep-2006


Page: 1 2

Related biology news :

1. NIH launches Knockout Mouse Project
2. Mouse model advances understanding of synovial sarcoma
3. Mouse FH knockout resembles human renal cell cancer
4. Mouse stem cell line advance suggests potential for IVF-incompetent eggs
5. Mouse model underestimates the critical role of Tyk2 in human immune system
6. Mouse DNA to aid biomedical research
7. Mouse strain with gene stutter will help leukemia research
8. Mouse mimics chronic leukemia, will aid drug development
9. Mouse, frog and bird put Snail and Slug to different uses
10. Mouse study reveals human X-SCID gene therapy poses substantial cancer risk
11. Mouse to man: The story of chromosomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... High dose of biotin may cause interference ... as cardiac troponin has serious clinical complications. There is an increasing trend of high ... unknown. , High dose of biotin supplement use may continue to increase due ...
(Date:10/3/2018)... YORK (PRWEB) , ... October 03, 2018 , ... ... in New York City, announces the appointment of healthcare visionary, Jimmy Lee, as ... leader with over 30 years of healthcare industry experience. As a Senior Executive ...
(Date:10/2/2018)... ... ... Stem Cell Innovations (SCI), a global network of professionals working together to ... the pre-sale for their ICO with participants purchasing SCIA Tokens for $0.15 ... stem cell specialists around the world. , SCI (formally Camden RAD, LLC.) ...
Breaking Biology News(10 mins):
(Date:10/13/2018)... ... October 12, 2018 , ... The ... education, innovation and commercialization, celebrates its 50th birthday in New York’s Times Square ... and Electro-Optics (ICALEO) conference. , In celebration of its 50 years, LIA ...
(Date:10/5/2018)... ... 04, 2018 , ... Karius , a life sciences ... at IDWeek™ 2018 the positive results of a study demonstrating that the Karius® ... causative pathogens in patients with infective endocarditis even when blood cultures were negative ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... Solutions™, LLC’s (Locus Bio-Energy) AssurEOR product line was chosen for its advancements in ... Energy Information, honor leading innovations in upstream oil applications that are positively impacting ...
(Date:9/28/2018)... ... September 28, 2018 , ... ... tech innovators, engineers, and scientists from around the world, is excited to announce ... of San Marcos, as the winner of the LabRoots Summer 2018 Textbook Scholarship, ...
Breaking Biology Technology:
Cached News: