HOME >> BIOLOGY >> NEWS
Lack of a key enzyme dramatically increases resistance to sepsis

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

The study was published in the April 20 edition of the journal Nature (Volume 440, Number 7087).

Richard Ulevitch, chair of the Scripps Research Immunology Department and an author of the paper, says, "The results of the study make clear that caspase-12 plays a critical role in the elimination of bacterial pathogens, and that a deficiency allows systemic and abdominal infections to be better resolved. It's known that the presence of caspase-12 as a full length protein occurs in a small percentage of people of African descent. As a result, some of these individuals are far more susceptible to severe sepsis and have a significantly increased risk of dying from it."

Sepsis, the body's inflammatory response to severe infection, is one of the leading causes of death in the United States, killing more than 200,000 people each year, according to the Society of Critical Care Medicine. A 2003 study by The Centers for Disease Control and Emory University School of Medicine showed that the incidence of sepsis in the United States has increased almost nine percent a year since 1979.

The new study showed that caspase-12 deficient mice were resistant to peritonitis and septic shock and were able to clear pathogenic bacteria more efficiently than mice with the enzyme. The presence of caspase-12 also reduced production of several pro-inflammatory cytokines, increasing vulnerability to bacterial infection and septic mortality.

"Without the experimental model of peritonitis perfected by John Mathison from Scripps Research, we woul
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
21-Apr-2006


Page: 1 2 3

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
3. NIEHS researchers identify enzyme critical in DNA replication
4. Scientists discover role of enzyme in DNA repair
5. Researchers create model of cancer-preventing enzyme, study how it works
6. Viral enzyme recruited in fight against ear infection
7. RNA enzyme structure offers a glimpse into the origins of life
8. Researchers create artificial enzyme that mimics the bodys internal engine
9. Scientists identify specific enzymes that make meningitis hard to fight
10. Fetal heart-cell enzyme important in onset of heart failure
11. Sentry enzyme blocks two paths to Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lack key enzyme dramatically increases resistance sepsis

(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. ... human interface solutions, today announced that Huawei has ... touchscreen solution for its stylish smartwatch. Huawei chose ... proven reliability, low power and highly responsive human ... finger. Huawei designers also required a classic round ...
(Date:7/27/2015)... LOS ANGELES , July 27, 2015 /PRNewswire/ ... providing evidence- and experience-based clinical improvement solutions, today ... coordination solution is now available on Android smartphones ... at inpatient and post-care organizations can use ZynxCarebook ... the same patient,s condition, streamline care transitions to ...
(Date:7/23/2015)... (NASDAQ: AWRE ), a leading supplier of biometrics software ... ended June 30, 2015.  Revenue for the ... 33% compared to $6.8 million in the same quarter last ... $0.3 million, or $0.01 per diluted share, which compared to ... period a year ago.  Lower revenue and ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
(Date:7/23/2015)... , July 23, 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... financial results for the second quarter 2015 on Thursday, August ... call and webcast on that day at 5:00 pm ET ... a business update. The call will be hosted by ... , , , LIVE CALL: , , ...
(Date:7/23/2015)... , ... July 23, 2015 , ... One hundred years ... the 1915 National Model Aeroplane Competition, with hopes of winning the Henry S. Villard ... its centennial. , Participants will have the opportunity to build a Free Flight fantasy ...
(Date:7/23/2015)... ... ... The Pittcon 2016 Program Committee is extremely pleased to announce that W. ... courtesy, of Applied Physics at Stanford University, will present the Wallace H. Coulter ... Cells and Beyond” , Dr. Moerner’s lecture will focus on his research in ...
(Date:7/23/2015)... OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS ... investors and the general public to its Annual Shareholder ... July 31, 2015. The meeting will be held at ... San Diego, California 92121.   ... be available. Please use the following link to register ...
Breaking Biology Technology:ImmunoCellular Therapeutics to Report Second Quarter 2015 Financial Results on August 6, 2015 2Academy of Model Aeronautics to Start Online Fantasy Flight Competition 2The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 2The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 3OncoSec to Webcast Annual Meeting of Stockholders 2
Cached News: