HOME >> BIOLOGY >> NEWS
Landmark comparative genomics study highlights the importance of 'junk' DNA in higher eukaryotes

SANTA CRUZ, Calif., Fri., July 15, 2005 A ground-breaking comparative genomics study appears online today in the journal Genome Research. Led by Adam Siepel, graduate student in Dr. David Haussler's laboratory at the University of California, Santa Cruz, the study describes the most comprehensive comparison of conserved DNA sequences in the genomes of vertebrates, insects, worms, and yeast to date.

One of their major findings was that as organism complexity increases, so too does the proportion of conserved bases in the non-protein-coding (or "junk") DNA sequences. This underscores the importance of gene regulation in more complex species.

The manuscript also reports exciting biological findings regarding highly conserved DNA elements and the development of a new computational tool for comparing several whole-genome sequences. It was authored by multiple investigators from leading research institutions, including Penn State University (University Park, PA), Washington University School of Medicine (St. Louis, MO), Baylor College of Medicine (Houston, TX), and the University of California, Santa Cruz.

One of the most powerful approaches for pinpointing biologically relevant elements in genomic DNA is to identify sequences that are similar across multiple species. Such approaches are particularly useful for analyzing non-protein-coding sequences sometimes called "junk" DNA. Although "junk" DNA is poorly understood, the increasing availability of whole-genome sequences is rapidly enhancing the ability of scientists to ascertain the biological significance of these non-protein-coding regions.

"Looking for functional elements in mammalian and other vertebrate genomes is like looking for needles in a haystack," explained Siepel. "By focusing on conserved elements, you get a much smaller haystack. It's not guaranteed to have every needle in it, and not everything in it is a needle, but you're much more likely to find
'"/>

Contact: Maria A. Smit
smit@cshl.edu
516-422-4013
Cold Spring Harbor Laboratory
14-Jul-2005


Page: 1 2 3 4

Related biology news :

1. Landmark study details demographic, ecological and genetic spread of rabies in raccoon outbreak
2. Landmark study identifies large number of new proteins implicated in Huntingtons disease
3. Landmark study highlights complex genetic risk factors behind type 2 diabetes
4. Landmark FSU study of hepatitis C virus solves mystery that has stymied quest for cure
5. National Science Foundation provides $14 million to advance research in comparative genomics
6. A comparative institutional analysis of intellectual property
7. How many comparative genomes are enough?
8. New comparative toxicogenomics database
9. DOE Joint Genome Institute secures long-term lease on production genomics facility
10. Bronfman gift to Mount Sinai catalyzes genomics-based medicine
11. New science of metagenomics will transform modern microbiology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... An upcoming episode ... in microbiome therapeutics are helping to promote normal immune function in order to ... will educate about the DECODE.DESIGN.CURE™ technology platform, which rapidly develops microbiome therapeutics in ...
(Date:8/14/2019)... TORONTO (PRWEB) , ... August 14, 2019 , ... Join ... live session on Tuesday, September 10, 2019 at 1pm EDT to learn ... stratification and effective management. , NAFLD is the most common diffuse liver disease, ...
(Date:8/14/2019)... ... 2019 , ... Gateway Genomics , a leading developer of direct-to-consumer genetic ... 38th annual Inc. 500|5000 list of fastest growing private companies, in the first ... founded and generating revenue by March 31, 2015. Ranking in the list is determined ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... ... ... At the most recent stem cell training course in Las Vegas ... Heroes Program. The Veterans included individuals and families from all over the US, with ... military Veteran, teacher or first responder to receive a regenerative therapy at a training ...
(Date:6/18/2019)... ... June 17, 2019 , ... ... entered into an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) ... rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 ...
(Date:6/11/2019)... Calif. (PRWEB) , ... June 10, 2019 , ... ... today announced IOPP will add 80 of its scientific journals to DeepDyve’s rental ... physics-related content to DeepDyve’s continually expanding library of more than 20 million articles, ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms ... cancer demand breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric ... with engineered T cell receptors known as “CARs”. The CAR enables the final product ...
Breaking Biology Technology:
Cached News: