HOME >> BIOLOGY >> NEWS
Landmark study highlights complex genetic risk factors behind type 2 diabetes

A UK collaboration of scientists has identified three new genes that predispose individuals to develop type 2 diabetes, bringing scientists a step closer towards understanding what causes this complex disease.

The study, jointly led by researchers at the University of Oxford and the Peninsula Medical School, Exeter, and forming part of the Wellcome Trust Case Control Consortium looked at over 2 billion pieces of genetic data and 6,000 people with type 2 diabetes and 8,000 controls to track down these three genes. In addition, they confirmed the link between the disease and a further two previously-identified genes.

The findings, published online today in the journal Science, bring the total number of genes known to be involved in type 2 diabetes to nine, including the FTO gene reported by the same UK group two weeks ago. The FTO gene influences individual risk of type 2 diabetes through its effect on weight and obesity.

Type 2 diabetes occurs as a result of a failure of the body to produce enough insulin to maintain normal levels of glucose (sugar) in the blood. This failure is usually compounded by a reduction in the capacity of the insulin released to work properly in tissues such as muscle and fat (known as insulin resistance). It is a major cause of heart disease and stroke, as well as blindness and kidney failure.

There are currently around 200 million people who have type 2 diabetes worldwide, yet its underlying cause is poorly understood, limiting both treatment and prevention. Lifestyle factors, such as poor diet and lack of exercise have been known for some time to increase risk of developing the disease, but scientists are becoming increasingly aware of the role played by genetics.

For each of the three genes described in the paper, the researchers have found that there are two common "versions", one of which is associated with an increased risk of developing type 2 diabetes, and the other with r
'"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
26-Apr-2007


Page: 1 2 3 4

Related biology news :

1. Landmark study details demographic, ecological and genetic spread of rabies in raccoon outbreak
2. Landmark study identifies large number of new proteins implicated in Huntingtons disease
3. Landmark FSU study of hepatitis C virus solves mystery that has stymied quest for cure
4. Landmark comparative genomics study highlights the importance of junk DNA in higher eukaryotes
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. Clones on task serve greater good, evolutionary study shows
7. Pollution causes 40 percent of deaths worldwide, study finds
8. A study by the MUHC and McGill University opens a new door to understanding cancer
9. New study suggests Concord grape juice may provide protection against breast cancer
10. Preclinical study links gene to brain aneurysm formation
11. In limiting life span, study finds booming bacteria innocent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/7/2020)... , ... April 07, 2020 ... ... announced the global launch of its DuPont™ YO-MIX® PRIME cultures series. These ... world. The versatile new solution helps them to address the multiple challenges ...
(Date:3/27/2020)... ... March 25, 2020 , ... ... platform to address the need to rapidly launch and scale COVID-19 clinical testing. ... consuming to deliver, has been adapted for COVID-19 specific content and user flows, ...
(Date:3/13/2020)... ... March 13, 2020 , ... ... lifespan of stored cord blood performed by Dr. Hal Boxmeyer and colleagues, which ... time for cryogenically preserved cells under proper conditions. Cryo-Cell International marks the first ...
Breaking Biology News(10 mins):
(Date:4/1/2020)... ... 30, 2020 , ... A joint venture between mobile health ... this year to bring telehealth to various government agencies, has now focused its ... are currently?awaiting an Emergency Use Authorization (EUA) waiver from the FDA?to?perform?AI?testing in the ...
(Date:4/1/2020)... ... March 31, 2020 , ... Carterra® Inc., the world leader ... announced today that they will use Carterra’s proprietary LSA™ platform to screen hundreds of ... clinic as early as this summer. , La Jolla Institute for Immunology (LJI) ...
(Date:3/27/2020)... ... March 25, 2020 , ... ... located centrally in the midwest for high-quality, quick-turn, board-certified reporting. In an ... motivated, independent, professional team that is focused on incredible quality, turnaround time ...
(Date:3/19/2020)... ... March 17, 2020 , ... ... gene circuit company Senti Biosciences, Inc. (Senti) to accelerate the clinical translation ... indications. The collaboration will leverage RoosterBio’s human mesenchymal stem/stromal cell (hMSC) bioprocess ...
Breaking Biology Technology:
Cached News: