HOME >> BIOLOGY >> NEWS
Leading cause of US food-borne illness makes its own pathway through cells

New Haven, Conn. -- Yale researchers now have some answers about how the bacterium that is the leading cause of food-borne illness in the United States enters cells of the gut and avoids detection and destruction, according to a presentation at the annual meeting of the American Society for Cell Biology in San Diego in December.

While scientists are just beginning to answer basic questions about how Campylobacter jejuni (campylobacter) causes infection, Robert Watson, a graduate student in the Section of Microbial Pathogenesis at Yale University School of Medicine worked out a better way to study the bacteria and reported that it takes an uncommon path as it infects cells.

Since the intestinal lining cells that campylobacter infects do not normally take up bacteria -- or any particles as large as bacteria -- Watson and his advisor, Jorge Galn, the Lucille P Markey Professor of Microbiology and Cell Biology, set out to investigate the path of infection through cells. They found that campylobacter apparently enters into the endocytic pathway that cells use to recycle molecules from their surface. It then quickly diverts its path, creating its own intracellular network of campylobacter-filled vacuoles, or cellular pockets, that make their way toward the nucleus, and finally locate near the cell's transportation hub, the Golgi apparatus.

"It's been known for over two decades that campylobacter can enter intestinal epithelial cells -- but until now no one could show how it was taken up or where it localized. That suggested it had evolved a special mechanism for uptake," said Watson. "Campylobacter seems to have found a special access to these cells and established its own intracellular niche."

The U.S. Centers for Disease Control and Prevention estimates that "campylobacteriosis," one of the most common causes of diarrhea worldwide, strikes 2.4 million Americans a year. Most sufferers recover after a few unpleasant days, but it can
'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
11-Jan-2007


Page: 1 2 3

Related biology news :

1. Leading the fight against food poisoning
2. Leading researchers honored for progress in cancer prevention, detection and treatment
3. Leading drug discovery and biotechnology scientists and experts discuss latest advancements
4. Leading scientists elected to EMBO ranks
5. Leading scientists gather to discuss developments in infectious disease research
6. Leading stem cell expert moves to UK
7. Leading breast cancer researcher awarded new lectureship
8. Leading experts confront global burden of chronic disease 8 Dec. at Abelson Science Seminar
9. Leading researchers from Israel and Southern California to present stem cell symposium
10. Leading experts present latest in cancer prevention research
11. Leading lampreys to slaughter: Pheromone for scourge of Great Lakes identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... , ... April 24, 2019 , ... ... announces today the award of U.S. patent 10,191,929, “Systems and Methods for SNP ... and more efficient to conduct a variety of advanced bioinformatic analyses, including SNP ...
(Date:4/18/2019)... and WALNUT CREEK, Calif. (PRWEB) , ... April ... ... management solution for the healthcare industry, today announced the launch of mSource® AI ... processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly optimizing purchased ...
(Date:4/16/2019)... ... April 16, 2019 , ... HealthLink International, experts ... its new medical device facility on Friday, April 12. Headquartered in the Netherlands, ... new facility includes 108,500 square feet and houses 32 employees enabling HealthLink to ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... , ... May 02, 2019 , ... ... testing company, will present results documenting discrepancies between U.S. insurer policies for genetic ... patients at risk for hereditary breast and ovarian cancer (HBOC). , ...
(Date:4/18/2019)... ... April 18, 2019 , ... Taking a step closer ... chemical engineer at Worcester Polytechnic Institute (WPI) has developed a novel process using ... manufacture isobutanol and other biofuels more economically. , Isobutanol, like ethanol, is an ...
(Date:4/12/2019)... ... April 12, 2019 , ... An upcoming episode ... educate about innovative tools and devices being used to enhance cognitive skills. This ... , This segment of Advancements will focus on Sound for Life, a neurotechnology ...
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny for short, ... two months. After a series of diagnostics, an MRI was performed which revealed ... researched the injury and found that VetStem Regenerative Cell Therapy may be ...
Breaking Biology Technology:
Cached News: