HOME >> BIOLOGY >> NEWS
Learning the language of DNA

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

A senior member of the consortium and IMB researcher Professor David Hume said transcriptome describes all of the information read from the genome by a cell at any given time.

"Essentially, we need to understand the language that cells use to read DNA in order to know how processes in the body are controlled," Professor Hume said.

"This knowledge will be a major resource to the biomedical research community."

Part of understanding the language of cells lies in identifying promoters - the DNA regions at the start of genes that regulate their activity.

"We have identified the core promoters of the large majority of genes in the mouse and human genomes, expanding the number of known promoters by five- to ten-fold," Professor Hume said.

The findings of the consortium have also upended the traditional view that each gene has a single promoter and a single starting position.

The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of start sites.

This new model may help explain why some organisms, such as humans, are much more complex than simple organisms such as worms, despite having a similar number of genes.

If some genes have a broad range of start sites, individual species can differ subtly in the way they control these genes, meaning the genes can evolve faster, and organisms with these genes can become more complex.

The consortium also found that many pseudogenes traditionally thought to be "fossils" of ancient genes are actually activ
'"/>

Contact: Professor David Hume
61-733-462-073
Research Australia
2-May-2006


Page: 1 2

Related biology news :

1. Learning to evolve: With a little help from my ancestors
2. Learning a second language -- Is it all in your head?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Learning how to help migrating swans find forage
5. Learning during sleep?
6. Learning how nature splits water
7. Learning global solutions to local problems
8. Learning to live with oxygen on early Earth
9. Learning the lessons of the worlds oldest ecological experiment
10. SNM Lifelong Learning and Self-Assessment program modules approved by ABNM, ABR for CME credit
11. Learning to love bacteria: Stanford scientist highlights bugs benefits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: