HOME >> BIOLOGY >> NEWS
Learning the language of DNA

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes.

A senior member of the consortium and IMB researcher Professor David Hume said transcriptome describes all of the information read from the genome by a cell at any given time.

"Essentially, we need to understand the language that cells use to read DNA in order to know how processes in the body are controlled," Professor Hume said.

"This knowledge will be a major resource to the biomedical research community."

Part of understanding the language of cells lies in identifying promoters - the DNA regions at the start of genes that regulate their activity.

"We have identified the core promoters of the large majority of genes in the mouse and human genomes, expanding the number of known promoters by five- to ten-fold," Professor Hume said.

The findings of the consortium have also upended the traditional view that each gene has a single promoter and a single starting position.

The team found that, while genes that are only turned on in a specific tissue or at a specific point in time use the traditional model of a single start site, genes used in many tissues have a broad distribution of start sites.

This new model may help explain why some organisms, such as humans, are much more complex than simple organisms such as worms, despite having a similar number of genes.

If some genes have a broad range of start sites, individual species can differ subtly in the way they control these genes, meaning the genes can evolve faster, and organisms with these genes can become more complex.

The consortium also found that many pseudogenes traditionally thought to be "fossils" of ancient genes are actually activ
'"/>

Contact: Professor David Hume
61-733-462-073
Research Australia
2-May-2006


Page: 1 2

Related biology news :

1. Learning to evolve: With a little help from my ancestors
2. Learning a second language -- Is it all in your head?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Learning how to help migrating swans find forage
5. Learning during sleep?
6. Learning how nature splits water
7. Learning global solutions to local problems
8. Learning to live with oxygen on early Earth
9. Learning the lessons of the worlds oldest ecological experiment
10. SNM Lifelong Learning and Self-Assessment program modules approved by ABNM, ABR for CME credit
11. Learning to love bacteria: Stanford scientist highlights bugs benefits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2019)... ... March 05, 2019 , ... Join this live ... metadata-driven approach will help data analysts and bioinformaticians focus on data analysis without worrying ... that can come from different source systems. Some sources of data include:, ...
(Date:2/27/2019)... ... February 27, 2019 , ... Fluxion Biosciences, a leading developer of precision solutions ... Cancer Institute grant for further development of its ERASE-Seq liquid biopsy technology. The Phase ... lab of Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... plans today to expand the company’s footprint in Frederick, MD after a year ... used RoosterBio’s adult human mesenchymal stem/stromal cell (hMSCs) products to streamline their product ...
Breaking Biology News(10 mins):
(Date:3/9/2019)... DIEGO (PRWEB) , ... March 07, 2019 , ... ... Technologies, is a pioneer in the development and commercialization of high performance, cutting-edge ... PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and electrophysiology, ...
(Date:3/5/2019)... Texas (PRWEB) , ... March 05, 2019 , ... ... a biopharmaceutical cold chain engineering firm with regulatory filing authorities, logistics network experts, ... corporate information to initiate its participation in the Inc. Verified Profile program, Inc. ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., a leading ... 140 employees on both the east and west coasts, today announced that employee ... New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., Anthony Whitesell, ...
(Date:2/22/2019)... ... February 20, 2019 , ... Superior Controls, Inc. ... solutions with 140 employees on both the east and west coasts, today announced the ... working out of the company’s Seabrook, New Hampshire office. In his new role, ...
Breaking Biology Technology:
Cached News: