Lehigh scientist receives NHGRI grant to streamline, expand use of genome sequencing

Dmitri V. Vezenov, assistant professor of chemistry at Lehigh University, was recently named recipient of a $905,000, three-year grant from the National Human Genome Research Institute (NHGRI).

Part of the National Institutes of Health, the NHGRI recently announced the latest round of $13 million in grants, which were awarded to speed the development of innovative sequencing technologies that reduce the cost of DNA sequencing and expand the use of genomics in medical research and health care.

A team led by Vezenov will apply force spectroscopy a technique used to measure intermolecular interactions and mechanical properties of polymer molecules to DNA that is undergoing arrested polymerization to initially demonstrate one-molecule-at-a-time analysis of changes in molecular mechanics. The ultimate goal of the project is to achieve a resolution of a single base.

Using optical, near-field probes, the methods of force spectroscopy can be advanced into techniques having a massively parallel format, in which millions of single DNA base additions can be followed at the same time. The identification of the bases will be done exclusively on the basis of changes experienced by the DNA molecule as a whole.

Vezenov's team aims to demonstrate a low-cost tabletop setup suitable for use in a general biology or hospital laboratory.

"Scanning force microscopy is a powerful tool with which to visualize the molecular and nano-world, but it cannot be used to 'read' the genetic code," says Vezenov. "In the last decade, advances in force spectroscopy a related technique have led to some interesting discoveries of the rich mechanical properties of single DNA molecules. We now know, for example, about a stretching transition in a DNA duplex that no one could have foreseen."

Vezenov says his group will try to answer a scientific question of the ultimate resolution that one can achieve when measuring forces in biomolecules: Can we

Contact: Linda Harbrecht
Lehigh University

Page: 1 2 3

Related biology news :

1. Lehigh receives $1.8 million from Howard Hughes Medical Institute for bioscience education
2. Doernbecher Childrens Hospital scientist earns coveted Javits award
3. UK scientists working to help cut ID theft
4. Smithsonian scientists show differing patterns of rainforest biodiversity
5. Weizmann Institute scientists discover a control mechanism for metastasis
6. Cornell scientists link E. coli bacteria to Crohns disease
7. UCLA scientists produce functioning neurons from human embryonic stem cells
8. ASBMB taps 8 scientists and 1 politician for top awards
9. UF, French scientists seek test to detect gene doping in athletes
10. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
11. Universes stringy birth revealed by young Czech scientist in EURYI winning project

Post Your Comments:

(Date:9/17/2019)... ... September 17, 2019 , ... VISTAAR released ADVISORY Playbooks to ... as re-assurance / 2nd opinion to their internal strategies they formed for developing or ... going into new markets, or planning to change their product elements and want to ...
(Date:9/17/2019)... ... September 17, 2019 , ... Last week, Blackrock Microsystems, LLC, ... the Medical University of Warsaw, met at the Presidential Palace of the Republic ... neuroprosthetic system as part of an initiative called "Startups in the Palace – ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified ... of the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding ... the Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... The EnozoPro® converts ordinary tap water ... germs and pathogens on hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. ... For more information, visit the product page at rovingblue.com , ”At Enozo, our mission ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... in vitro toxicology testing solutions, announced the appointment of Mark McLoughlin to the ... the Board. , Mark McLoughlin will lend his healthcare expertise and extensive background ...
(Date:8/7/2019)... ... , ... Locus Agricultural Solutions (Locus AG) reports record levels of carbon sequestered ... Rhizolizer ® , which is pulling up to 121% more carbon into the soil ... Results from the treatment of almonds, cherries, turf/sod, grapes and citrus across the U.S., ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a ... a distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the ... July/August special issue. , As the executive vice president of business development and ...
Breaking Biology Technology:
Cached News: