HOME >> BIOLOGY >> NEWS
Life and death in the hippocampus: what young neurons need to survive

Whether newborn nerve cells in adult brains live or die depends on whether they can muscle their way into networks occupied by mature neurons. Neuroscientists at the Salk Institute for Biological Studies pin-pointed the molecular survival gear required for a young neuron to successfully jump into the fray and hook up with other cells.

In a study published in a forthcoming issue of Nature, researchers in the lab of Fred H. Gage, Ph.D., a professor in the Gene Expression Laboratory and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases, identify a subunit of the NMDA receptor, a protein complex that transduces signals sent by neighboring cells, as the cells' life-saving equipment that allows them to integrate into the existing brain circuitry.

The NMDA receptor is activated by the neurotransmitter glutamate, a chemical released by neurons in order to transmit information to neighboring cells. Whenever the receptor picks up a glutamate signal it is stimulated and relays the signal. But for newborn neurons that signal means something else entirely -- survival.

"When we removed the NMDA receptor, that is when cells make connections in response to glutamate in the environment, the newborn neurons withered and died at a specific stage of their maturation," explains Gage. " The NMDA receptor modulates synapse formation and determines what pattern of input activity new neurons receive, which in turn determines survival or death."

Combining mouse genetics and gene transfer techniques, Gage and a team headed by former postdoctoral fellow Ayumu Tashiro, Ph.D., injected a virus carrying a pair of molecular shears capable of deleting a gene encoding part of the NMDA receptor into the hippocampus, a brain region harboring neural stem cells that give rise to new neurons. Newly born neurons infected with virus were marked by a fluorescent dye enabling detection of neurons derived from those cells.

'"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
13-Aug-2006


Page: 1 2 3

Related biology news :

1. Pollution causes 40 percent of deaths worldwide, study finds
2. Inflammation may cause preterm labor and fetal deaths
3. Bacteria may not hasten death
4. Study points to new way to predict death risk from torn aorta
5. Ethnicity plays a role in neonatal deaths
6. Antibody retards growth and induces death in liver cancer cells
7. Specific type of cell death may accelerate decompensated heart failure
8. Lung and bladder cancer deaths continue decades after arsenic exposure
9. Agonized death throes probable cause of open-mouthed, head-back pose of many dino fossils
10. Cells re-energize to come back from the brink of death
11. Common cancer gene sends death order to tiny killer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a critical ... discover a COVID cure or vaccine, the global economic downturn will only increase price ... not going away and capturing full value from every product launch is critical. However, ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced ... will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional ... Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... access to competitively procured purchasing contracts to its membership, recently named BioFit ... TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks ...
(Date:6/28/2020)... NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... announced the launch of Safe Space™ for businesses of all types to ensure cleanliness, ... 3D LiDAR. , A Safe Space™ enabled business will provide a health ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... photodynamic therapy for treating cancer, today announced the company has entered a license ... The agreement provides Lumeda globally exclusive rights to Roswell Park intellectual property ...
(Date:6/23/2020)... ... June 23, 2020 , ... Kerafast Inc. , developers ... announced the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The ... of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 ...
Breaking Biology Technology:
Cached News: