HOME >> BIOLOGY >> NEWS
Linchpin discovered in insulin metabolism

Scientists from the new interdisciplinary LIMES (Life & Medical Sciences) Centre at the University of Bonn have identified a new gene which could play an important role in the development of diabetes. Flies in which this hereditary factor is defective are also significantly smaller than other members of their species and live appreciably longer. The gene seems to have such a crucial function that it has hardly changed in just under a billion years: it is found in flies, but in a similar form it is also found in mice and humans. In the current issue of the prestigious journal Nature the Bonn researchers have published two articles on this topic.

Sometimes science resembles a relay race: in 1996 the biochemist Professor Waldemar Kolanus discovered a group of cellular proteins, the cytohesins, and described their function in the immune system. Two of his colleagues at the LIMES Centre in Bonn have now found a totally new and completely unexpected function of these proteins which is very relevant to medicine. 'We wanted to know whether there were also cytohesins in the fruit fly drosophila and what functions they have there,' the evolutionary biologist Professor Michael Hoch reminisces. He and his team were in fact successful. They discovered a protein which is very similar to the cytohesins in mammals. Even more interestingly, fruit flies in which the genetic blueprint for this gene is defective are smaller in size. So the researchers nicknamed cytohesin 'Titch'. 'The effect on the insect's growth showed us that 'Titch' could play a key role in the metabolism of insulin a completely new role for cytohesins,' Professor Hoch says.

New drugs for diabetes

The maximum size of plants or animals is written into their genes. Yet whether they exploit this potential is influenced by a number of other factors. One of them is insulin. Mammals produce increased amounts of this hormone after eating as a reaction to the increasing blood sugar
'"/>

Contact: Michael Hoch
m.hoch@uni-bonn.de
49-228-734-621
University of Bonn
15-Dec-2006


Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A new brake on cellular energy production discovered
3. New target for HIV/AIDS drugs and vaccine discovered
4. Surprising new species of light-harvesting bacterium discovered in Yellowstone
5. Scratch no more: Gene for itch sensation discovered
6. Fruit fly gene from out of nowhere is discovered
7. A novel molecular dictator with a conscience discovered
8. Gene discovered for type 1 diabetes in children
9. Alzheimers prevention role discovered for prions
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic fellow traveler discovered in Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Linchpin discovered insulin metabolism

(Date:8/19/2015)... , Aug. 19, 2015  VOXX International Corporation ... has entered into a Definitive Agreement to purchase ... iris authentication market leader EyeLock through an acquiring ... have a controlling interest in the acquiring entity. ... completion of due diligence.  Expanding on its existing ...
(Date:8/12/2015)... Minn. , Aug. 12, 2015   MedNet ... supports the entire spectrum of clinical research, is proud ... , the company,s comprehensive SaaS-based eClinical technology platform, has ... during the first two quarters of 2015.   Q2 ... second largest quarters measured by contract value sold in ...
(Date:8/11/2015)... Today, ZUK announced its Android smartphone Z1, ... expected revenues in 2015 that relate to sales of FPC1155 for ... approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO of ... smartphone manufacturer in China and ... 155 for Z1 , ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5MedNet Solutions Experiences Explosive Corporate Growth 2FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
(Date:8/31/2015)... Trimb Healthcare AB ("Trimb") today announced that ... BV ("YouMedical"), a Dutch OTC company with operations in ... approximately EUR 16 million, with solid growth and leading ... is to build a leading international OTC company, and ... YouMedical gives us a stronger North European OTC platform, ...
(Date:8/30/2015)... , August 31, 2015 ... einer Frau   für chirurgische   Behandlung     ... 7-90   werden für eine   verheerende   ... Frauen behandeln und die Anzahl ausgebildeter Chirurgen in Kenia ... Astellas gab heute bekannt, dass  Action on Fistula  seit ...
(Date:8/28/2015)... , Aug. 28, 2015 /PRNewswire/ - RepliCel ... stage regenerative medicine company focused on the development ... for the quarter ended June 30, 2015, corporate ... and management report are available at www.sedar.com ... . "RepliCel expects to launch ...
(Date:8/27/2015)... 27, 2015  Neogen Corporation (NASDAQ: NEOG ) ... United Kingdom -based Lab M Holdings, ... and diagnostic systems. Lab M was ... provider of microbial testing and diagnostic products for the ... company currently sells into more than 70 countries worldwide, ...
Breaking Biology Technology:Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5Neogen acquires U.K.-based Lab M Holdings 2
Cached News: