Linchpin discovered in insulin ...( in the Nature paper could help in the s...)

Linchpin discovered in insulin metabolism

in the Nature paper could help in the search for this kind of drug. With its help his team has already found the inhibitor SecinH3.

A long life thanks to a genetic defect"

The joint ancestor of the fruit fly and the mouse lived at least 900 million years ago. Nevertheless, 'Titch' and the corresponding cytohesin in mice are so similar that SecinH3 is effective with both. 'We have fed the inhibitor to our fly larvae,' Michael Hoch explains. 'They then developed as if their 'Titch gene' were defective.' This hereditary factor also has a completely different effect, which really sets the researchers' imagination going. Flies which have a 'Titch' defect live a lot longer than others of their species. 'An exciting effect,' Michael Hoch thinks. 'We certainly must investigate this further.'

Contact: Michael Hoch
m.hoch@uni-bonn.de
49-228-734-621
University of Bonn
15-Dec-2006

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