HOME >> BIOLOGY >> NEWS
Link between immune system and mammary gland could shed new light on breast cancer

Scientists at the University of Cambridge have published new research today (5 July) in the journal Development showing an unexpected link between a fundamental part of the immune system and the cells that produce milk in the breast during lactation.

The researchers, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), found that cytokines, which have a central role in immune response, are used in the breast to promote the production of milk producing cells. The finding has implications for understanding breast cancer as cells that respond incorrectly to cytokine signalling can grow out of control and become cancerous.

When the body needs to fight infection it makes specific cells that respond to the invading organism. These cells are either T helper Type 1 to fight a virus or T helper Type 2 to attack a parasite. Once made each type of T cell releases cytokine molecules to promote more of its own kind to help the bodys immune response. The Cambridge researchers have shown that during pregnancy the mammary gland uses this system to enhance the growth of milk producing cells.

The breast uses Type 2 T helper cytokines as a signal to get resting mammary duct cells to begin dividing and differentiating to produce large numbers of milk-producing cells. These cells then release more cytokine molecules to get the body to make yet more milk producing cells. Using a mouse model, the scientists were able to conclusively demonstrate the role of the Type 2 cytokines. When the signalling molecules were not present, production of milk producing cells was vastly reduced.

Dr Walid Khaled from the Universitys Department of Pathology conducted the research. He explains: This really was an unexpected discovery. Up until now we thought that breast development was controlled by just steroid and peptide hormones. The discovery of this role played by aspects of the immune system will open up new avenues for examining the
'"/>

Contact: Matt Goode
press.office@bbsrc.ac.uk
44-179-341-3229
Biotechnology and Biological Sciences Research Council
4-Jul-2007


Page: 1 2

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Link between sunspots, rain helps predict disease in east Africa
3. Link identified between Alzheimers disease and glaucoma
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Human knowledge is based upon directed connectivity between brain areas
6. First case of successful ovarian tissue transplantation between two, nonidentical sisters
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. MIT IDs link between brain tumor proteins
9. Co-operation between GSF and clinic improves outlook for sarcoma patients
10. FDA finds no strong link between tomatoes and reduced cancer risk
11. Satellite images reveal link between urban growth and changing rainfall patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2020)... ... March 11, 2020 , ... USARAD Holdings ... Siemens Healthineers and several healthcare VC firms introduces a first of its kind ... 100 countries and has caused over 4,000 fatalities to date. Over the years, ...
(Date:3/9/2020)... ... March 09, 2020 , ... ... growth rate of 64% last year, as enterprises sought to achieve competitive ... Group. Unfortunately, only 13% of all transformation efforts delivered the intended consequences. ...
(Date:3/5/2020)... , ... March 05, 2020 , ... Patients in need ... dental implants from Dr. Nickelice Brand of Dental Implants of Ocala. Same-day dental ... get an entirely new smile in just one day. This treatment utilizes advanced technology ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... ... Join Forrest Brown, Engineering Services Manager – Northeast Region and Jarred Christofaro, Engineering ... session on Wednesday, February 26, 2020 at 1pm EST to learn about:, ... add manufacturing flexibility in the future, especially for CMOs , C&Q Strategy ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... the launch of a new and unified global brand identity, as it celebrates ... complex engineering challenges, as well as an enthusiasm for designing and manufacturing state-of-the-art ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... from a long-term follow-up clinical study of outpatient L4-L5 lumbar interspinous fixation ... Unlike extension block design, the Inspan device fixates the spine to allow ...
(Date:2/5/2020)... FARMINGTON, Conn. (PRWEB) , ... February 04, 2020 ... ... that develops tools for characterizing microbiome populations down to the strain level, has ... Limited, will sell Shoreline Biome’s microbiome kits and other products to companies and ...
Breaking Biology Technology:
Cached News: