HOME >> BIOLOGY >> NEWS
Link identified between Alzheimer's disease and glaucoma

UK scientists have shown for the first time that key proteins involved in Alzheimer's disease are also implicated in glaucoma, the major cause of irreversible blindness worldwide. Research carried out at the UCL Institute of Ophthalmology and funded by the Wellcome Trust has also shown that novel drugs being trialled for Alzheimer's disease which target this protein may be used to treat glaucoma.

The research team has developed a new technology for visualising nerve cell damage in the retina, known as Detection of Apoptosing Retinal Cells. Using this technology, they demonstrated that the protein beta-amyloid, which causes the so-called "plaque" lesions in the brains of Alzheimer's patients, also leads to nerve cell death in the retina. The research is published online today in the journal Proceedings of the National Academy of Sciences of the USA.

"We've seen for the first time that there is a clear link between what causes Alzheimer's disease and one of the basic mechanisms behind glaucoma," says Dr Francesca Cordeiro from University College London, who led the study. Dr Cordeiro is also a consultant ophthalmologist at the Western Eye Hospital, London, specialising in glaucoma. "However, this doesn't mean that everyone with Alzheimer's will develop glaucoma or vice versa. Glaucoma has a number of risk factors."

Glaucoma affects over half a million in the UK and as many as 65 million people worldwide(1). Little is know about what exactly causes the disease, which causes damage to the optic nerve in the eye; although the disease is traditionally attributed to increased pressure in the eye (known as "intraocular pressure", and clinical treatments attempt to lower this pressure). However a significant number of patients continue to lose vision despite their pressure being well controlled. The new research opens up a new avenue of treatment in glaucoma which does not involve treating intraocular pressure.

Dr Cordeiro and colle
'"/>

Contact: Mike Findlay
m.findlay@wellcome.ac.uk
44-207-611-8612
Wellcome Trust
6-Aug-2007


Page: 1 2

Related biology news :

1. Gene identified for Crohns disease in children
2. New gene mutation identified in common type of dementia
3. Allergy molecule identified
4. Gene responsible for common hearing loss identified for first time
5. Muscle weakness: New mutation identified
6. Tumor vessels identified by unique molecular markers
7. Extra-aggressive form of idiopathic pulmonary fibrosis identified
8. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
9. Pediatric cancer stem cell identified: understanding the origin of ERMS
10. New host species for avian influenza identified
11. Master regulatory gene of epithelial stem cells identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... California (PRWEB) , ... October 10, 2017 , ... Dr. ... speaking at his local San Diego Rotary Club. The event entitled ... Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by ...
Breaking Biology Technology:
Cached News: