The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Linking DNA and histone methylation

In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.

Dr. Carey emphasizes that "The study provides a new direction to understand how histone and DNA methylation, two phenomena that play a significant role in stem cell differentiation and cancer, can communicate with each other to turn genes off. "

Although both histone and DNA methylation have long been recognized as hallmarks of euchromatic gene silencing, how these two processes cooperate to induce silencing has remained unresolved. In their upcoming paper, Dr. Carey and colleagues detail that mammalian HP1 proteins facilitate this cooperation.

They found that HP1 proteins, which bind to methylated histones, also interact with the DNA methyltransferase, DNMT1, to stimulate its DNA methylation activity. DNMT1, in turn, reinforced HP1 binding to methylated histones. Finally, the researchers showed that DNMT1-stimulated HP1 binding is required for gene silencing.


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
29-Apr-2007


Page: 1

Related biology news :

1. Linking brain to mind in a common genetic disease
2. Linking empires, economics, evolution
3. Stowers Institutes Workman Lab demonstrates mechanism for decoding histone modification marks
4. Coordinating DNA and histone methylation
5. The meiotic histone code
6. ASBMB Schering-Plough Award lecture to focus on histone modifications in transcription
7. In Nature paper, scientists at U.Va. health system crack part of histone code

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Linking DNA and histone methylation

(Date:11/23/2009)...RE, Calif. - By producing some of the highest reso...faces, scientists have a deeper understanding how ...research may lead to a new treatment for kidney st...ppears in the Nov. 23 online edition of the journa... , explores how peptides interact with mineral sur...
(Date:11/23/2009)...MINGHAM, Ala. A new study by University of Alabam...mass index (BMI) and co-existing medical condition...ival observed among African-Americans compared to ...s published online Nov. 23 in Cancer , a journal ...dicates that although BMI and co-morbidity are ind...
(Date:11/23/2009)...GN, Ill. Two new studies reveal in unprecedented ...ules to assemble new proteins and guide them towar...es used molecular dynamics flexible fitting (MDFF)...wo prominent molecular partners. , The first st...iences , concerns the intimate signaling between t...
Breaking Biology News(10 mins):Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 2Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 3Racial disparity in colon cancer survival not easily explained, UAB researchers say 2Computational microscope peers into the working ribosome 2Computational microscope peers into the working ribosome 3Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 13449 1Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 13449 2Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 13449 3Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 1Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 2Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 3Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 4Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 5Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 6Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 7Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 1Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 2Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 3Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 4Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 5Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 6Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 7Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 8Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 9Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 10Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 11Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 12Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 13Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 14Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 15Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 16Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 17Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 18
(Date:11/24/2009)...ntly approved the Promega PowerPlex 16 HS System f...ing DNA records for the National DNA Index System....) -- The FBI recently approved the Promega PowerP...ticipating in, or generating DNA records for, the ...ontains more than seven million profiles and has a...
(Date:11/24/2009)...irstCall/--Shireplc(LSE:SHP,NASDAQ: SHPGY ),thegl...cedthatithassubmittedaMAAtotheEuropeanMedicinesAge...menttherapyindevelopment,forthetreatmentofType1Gau...velaglucerasealfathathasbeensubmitted,withprevious...edonaglobalsupplyshortageofthecurrentlyapprovedand...
(Date:11/24/2009)...ire/--HealthRoboticstodayannounced,thatithasformed...tors.ThisrecentlyformedToronto-basedcompanywillope...arket,install,andsupport,HealthRobotics,i.v.Roomof...ductofferingsi.v.STATION(TM),i.v.SOFT(TM),andOMM(T...nceonan"asneeded,basis"toitsstrategicpartnershipsw...
(Date:11/24/2009)...tCall/--CellTherapeutics,Inc.(CTI)(NasdaqandMTA:CT...yHealthCareConference.TheconferencewillbeheldDecem...presentonTuesday,December1at11:00a.m.EasternTimein...tionwillbeavailableat www.celltherapeutics.com ,an...erJaffrayHealthCareConference,NewYorkPalaceHotel,H...
Breaking Biology Technology:NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3Health Robotics Continues its Global Expansion With December 09 ASHP's Launch of Joint Venture in Canada 2
Other News:
...g neurological disorder occurring primarily in gir...cular symptoms of the condition, there is no curre...l. Now, researchers at Whitehead Institute for Bio... at Brandeis University, have dramatically reduced...
...dren's Hospital Medical Center have discovered the...is, one of a number of eosinophil-related diseases...ts of white blood cells that can lead to allergy r... esophagus is overwhelmed with white blood cells a...
...rom SIDS (sudden infant death syndrome) in African...d half of those deaths result from a common geneti...eloping an abnormal heart rhythm during times of e...University of Chicago reports in the February 2006...
...e leading clinical publication on the disease, pub...ng (BEST) Study at The University of Arizona which...ng and resistance exercises, combined with calcium...ificant improvement in bone mineral density (BMD) ...
Researchers alleviate symptoms of Rett syndrome in mice 2Researchers alleviate symptoms of Rett syndrome in mice 3Gene discovery linked to increasingly diagnosed gastrointestinal disease 2Gene discovery linked to increasingly diagnosed gastrointestinal disease 3Gene variation increases SIDS risk in African Americans 2Gene variation increases SIDS risk in African Americans 3Researchers show the 'BEST' way to reduce osteoporosis risk 2Researchers show the 'BEST' way to reduce osteoporosis risk 3
... among us...George Hudler, a Cornell University pr...his new, mycological book, "Magical Mushrooms, Mis...)," the story of the fungus kingdom and its.impact...y of Minnesota lecture-and-lab class on forest.pat...
... .Bronx-Based Organization Focuses on Cons...00 Miles of New York City .NEW YORK, N.Y., Decembe... Bronx,.New York, today received a three-year, $70...ion to incorporate ecosystem and biological resear...
... . Blacksbur...inia).Elementary School (CES) wanted to start a wi...r its students, it turned to an old friend, Virgin...es. The college, through its.Wildlife Society stu...
...e 18 December 1998 issue, the editors of Science.w...mportant advances in science.research. Heading the...that.galaxies of the cosmos are flying apart at ev...advances from the past twelve months that have pro...
Professor Authors Complete Guide To Fungi 2Professor Authors Complete Guide To Fungi 3Wildlife Conservation Society Receives $700,000 Grant From Doris Duke Charitable Foundation 2Elementary Students Mapping Virginia Wildlife 2Science Announces Top Ten Research Advances Of 1998 2Science Announces Top Ten Research Advances Of 1998 3Science Announces Top Ten Research Advances Of 1998 4Science Announces Top Ten Research Advances Of 1998 5