HOME >> BIOLOGY >> NEWS
Lipid plays big role in embryonic development

A little-known lipid plays a big role in helping us grow from a hollow sphere of stem cells into human beings, researchers have found.

They found that in the first few days of life, ceramide helps stem cells line up to form the primitive ectoderm from which embryonic tissues develop, says Dr. Erhard Bieberich, biochemist at the Medical College of Georgia.

Probably 90 percent of ceramide gathers at the top or apical end of these early stem cells, literally helping cells have direction. "We have cell polarity, an up and down, a head and foot of the cell, and that is what ceramide most likely regulates," says Dr. Bieberich. "Cell polarity is absolutely essential for differentiation; otherwise you have a ball of cells, not organized tissue."

In fact, we start out as a wad of cells, but within 24 hours, some cells die and others become part of the hollow sphere with an inner layer -- the primitive ectoderm -- that will further differentiate into an embryo, and an outer layer -- the primitive endoderm -- that sustains the embryo during development.

"Ceramide distributes to the apical end of the cell," says Kannan Krishnamurthy, MCG graduate student and first author of the study published in the Feb. 2 issue of the Journal of Biological Chemistry. "In this case, the basal end, or lower end, is attached to the outer layer while the apical end points toward the sphere's cavity."

Cells make ceramide, which researchers are finding has many different jobs in the developing and mature body. Like other lipids, it helps make up membranes throughout the body, it has an insulation role in the skin and it is a precursor for the protective coating of nerves, called myelin.

"There is more and more evidence that ceramide not only is a structural lipid but a messenger involved in signal transduction, in telling proteins what to do," says Dr. Guanghu Wang, MCG research assistant scientist who shares first authorship.'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
2-Feb-2007


Page: 1 2

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. Story ideas from the Journal of Lipid Research
3. Beyond genes: Lipid helps cell wall protein fold into proper shape
4. Lipids get new comprehensive classification system
5. Ethnicity plays a role in neonatal deaths
6. Research study describes the role part of the brain plays in memory
7. Clock gene plays role in weight gain, study finds
8. Researchers identify gene that plays key role in size of dogs
9. Motor protein plays key role in connecting neurons
10. Study identifies glucose sensor that plays dual role in glucose metabolism and fat synthesis
11. Fish species plays surprise role in aiding coral reef recovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Disappearing forests ... the lives of over 5.5 million people each year. Especially those living in larger ... startup Treepex - based in one of the most pollution-affected countries globally - decided ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
Breaking Biology Technology:
Cached News: