HOME >> BIOLOGY >> NEWS
Lipid plays big role in embryonic development

A little-known lipid plays a big role in helping us grow from a hollow sphere of stem cells into human beings, researchers have found.

They found that in the first few days of life, ceramide helps stem cells line up to form the primitive ectoderm from which embryonic tissues develop, says Dr. Erhard Bieberich, biochemist at the Medical College of Georgia.

Probably 90 percent of ceramide gathers at the top or apical end of these early stem cells, literally helping cells have direction. "We have cell polarity, an up and down, a head and foot of the cell, and that is what ceramide most likely regulates," says Dr. Bieberich. "Cell polarity is absolutely essential for differentiation; otherwise you have a ball of cells, not organized tissue."

In fact, we start out as a wad of cells, but within 24 hours, some cells die and others become part of the hollow sphere with an inner layer -- the primitive ectoderm -- that will further differentiate into an embryo, and an outer layer -- the primitive endoderm -- that sustains the embryo during development.

"Ceramide distributes to the apical end of the cell," says Kannan Krishnamurthy, MCG graduate student and first author of the study published in the Feb. 2 issue of the Journal of Biological Chemistry. "In this case, the basal end, or lower end, is attached to the outer layer while the apical end points toward the sphere's cavity."

Cells make ceramide, which researchers are finding has many different jobs in the developing and mature body. Like other lipids, it helps make up membranes throughout the body, it has an insulation role in the skin and it is a precursor for the protective coating of nerves, called myelin.

"There is more and more evidence that ceramide not only is a structural lipid but a messenger involved in signal transduction, in telling proteins what to do," says Dr. Guanghu Wang, MCG research assistant scientist who shares first authorship.'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
2-Feb-2007


Page: 1 2

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. Story ideas from the Journal of Lipid Research
3. Beyond genes: Lipid helps cell wall protein fold into proper shape
4. Lipids get new comprehensive classification system
5. Ethnicity plays a role in neonatal deaths
6. Research study describes the role part of the brain plays in memory
7. Clock gene plays role in weight gain, study finds
8. Researchers identify gene that plays key role in size of dogs
9. Motor protein plays key role in connecting neurons
10. Study identifies glucose sensor that plays dual role in glucose metabolism and fat synthesis
11. Fish species plays surprise role in aiding coral reef recovery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... 2017  New research undertaken by Fit Small Business ... 1,000 participants were simply asked which office technology had they ... consider standard issue.  Insights on what will be ... from futurists and industry leaders including Penelope Trunk , ... Some of these findings included; ...
(Date:1/11/2017)... 11, 2017 Intoxalock, a leading ignition interlock ... of its patent-pending calibration device. With this new technology, ... securely upload data logs and process repairs at service ... "Fighting drunk driving through the application of cutting-edge ... large, but also for the customer who can get ...
(Date:1/6/2017)... Calif. , Jan. 6, 2017  Privately-held ... safety studies in healthy volunteers of a novel ... to treat acute pancreatitis. Acute ... typically a mild disorder, but can be very ... failure and sepsis, where extended hospital stays, time ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... 2017 , ... November Research Group, LLC, a global leader ... manufacturers and regulators, is proud to announce the worldwide release of PRIMO Mail. ... provide product vigilance departments with the flexibility and ease of use of a ...
(Date:1/19/2017)... Linda, Ca (PRWEB) , ... January 18, 2017 ... ... virtual events for tech innovators, engineers, and scientists from around the world, was ... American News. The awards program is based entirely on merit and decided upon ...
(Date:1/19/2017)... -- Acupath Laboratories, Inc., a leading provider of sub-specialized ... Committee that will guide the company,s vision and strategy ... , a 15-year veteran of the anatomic pathology industry, ... Chief Sales Officer .  Prior to joining Acupath ... leadership roles at several leading lab industry organizations including, ...
(Date:1/18/2017)... Jan. 18, 2017 Applied BioMath ( ... to drug research and development, today announced that ... and CEO of Applied BioMath, will present at ... Modeling (BAGIM) Meeting on Thursday January 19, 2017 ... , MA.   Dr. Burke,s talk "Quantitative Modeling ...
Breaking Biology Technology:
Cached News: