HOME >> BIOLOGY >> NEWS
Live broadcasts

To help molecular biologists in the difficult task of keeping abreast of current events in the world of cells and organisms, they employ reporter genes to 'broadcast' specific happenings. For example, if a scientist is interested in the whereabouts and activities of a certain gene, the reporter 'follows' it, and when this gene is activated in any way, the reporter gene produces an easily detectable protein, such as green fluorescent protein (GFP). The scientists are then able to 'read' this 'report' and learn about the specific events that are occurring and in what regions.

The light given off by these proteins is scattered in the tissue, however, reducing the resolution of many images. An alternative to fluorescent proteins is reporters that would be detectable via magnetic resonance imaging (MRI). But for most of the candidate reporters proposed so far, a second material needs to be administered in addition to the reporter gene to allow the MRI to detect its signals. Unfortunately, processes such as fetal development and those that take place within the central nervous system present barriers to these additional substances.

Prof. Michal Neeman and Dr. Batya Cohen of the Weizmann Institutes Biological Regulation Department, along with Ph.D. students Keren Ziv and Vicki Plaks and colleagues, have now developed genetically modified mice that carry a promising candidate reporter named ferritin, which could circumvent these problems. Ferritin works by sequestering iron from cells. When it is overexpressed, iron uptake increases, causing signal changes in the surrounding environment that can be detected by MRI, without the need to administer an additional substance.

As recently described in the journal Nature Medicine, ferritin has so far successfully broadcast live reports via MRI detection from the liver, endothelial cells and even during fetal development in pregnant mice, without the need for additional substances.


'"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
26-Jul-2007


Page: 1

Related biology news :

1. Study identifies energy efficiency as reason for evolution of upright walking
2. Brightly colored birds most affected by Chernobyl radiation
3. Bright future for nano-sized light source
4. Wright State scientist receives grant to help clean up polluted American harbors
5. Human ancestors learned to walk upright in the trees, say experts
6. Lessons from the orangutans: Upright walking may have begun in the trees
7. Left-right wiring determined by neural communication in the embryonic worm
8. Genes and biomarkers that allow doctors to choose the right therapy for the right patient
9. Malaria: The right vaccine in the right place?
10. Traveling in the right direction -- lessening our impact on the environment
11. Trusting your instincts leads you to the right answer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: