HOME >> BIOLOGY >> NEWS
Living view in animals shows how cells decide to make proteins

DURHAM, N.C. -- Scientists at Duke University Medical Center have visualized in a living animal how cells use a critical biological process to dice and splice genetic material to create unique and varied proteins.

The scientists say the findings, made in mice, help explain a key wonder of human biology: how the same genes found in every cell of an individuals body can produce different proteins in different tissues and organs. These varied proteins, in turn, dictate the function of each tissue or organ.

The findings also may offer insight into a number of diseases, including cancer, in which the genetic process -- called alternative splicing -- goes awry and produces the wrong proteins, the scientists said.

The scientists published the findings in the Dec. 1, 2006, issue of the journal RNA. The study was funded by the National Institutes of Health.

Scientists previously have examined alternative splicing in cells and tissues in test tubes, but this study marks its first successful visualization in a living mammal, said senior investigator Mariano Garcia-Blanco, M.D., Ph.D., a professor of molecular genetics and microbiology.

"We were able to watch alternative splicing as it occurred in different tissues," he said. "Its an excellent example of how experiments in living organisms provide a much more complete picture of how genes and proteins behave than do experiments using cells in culture."

Until 20 years ago, scientists believed that a single gene made a single protein. With the discovery of alternative splicing, it became clear that one gene can produce multiple proteins.

In alternative splicing, microscopic "scissors" in a gene chop the genetic material RNA into bits called "exons" and then reassemble the bits in a different order to form a new RNA molecule. In the process, some of the exons are retained while others are excluded. The exons that are retained in the final RNA determine which
'"/>

Contact: Becky Levine
levin005@mc.duke.edu
919-660-1308
Duke University Medical Center
30-Nov-2006


Page: 1 2 3

Related biology news :

1. Study: Living coral reefs provide better protection from tsunami waves
2. Living laboratory found on shoreline statues
3. New scientific challenges and goals for ESAs Living Planet Program
4. Living with Climate Variability and Change
5. Living Oceans Foundation leads Red Sea expedition
6. Living taste cells produced outside the body
7. Living fossil roams the seas
8. Living with salt
9. Limpets reveal possible fate of cold-blooded Antarctic animals
10. Killing only a few animals wont do any harm -- or will it?
11. Massive herds of animals found to still exist in Southern Sudan

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... At its ... Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has ... was a member of the winning team for the 2015 Breakthrough Prize in Fundamental ...
(Date:10/9/2017)... Antonio, Texas (PRWEB) , ... ... ... new study published on October 5, 2017, in the medical journal, Epilepsia, ... equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic seizures ...
Breaking Biology Technology:
Cached News: