Location, location, location: Effect of nuclear organization on transcriptional status

Dr. Pamela Silver and colleagues have taken a systems approach to address the correlation between a gene's location in the nucleus and its transcriptional activity. In a poignant example of how the nuclear organization of yeast genes change when the cell undergoes a dramatic switch in its transcriptional program, Dr. Silver and colleagues treated S. cerevisiae cells with the mating pheromone, alpha factor, and then used genome-wide location analysis to observe that alpha-factor-responsive genes became associated with nuclear pore components.

This finding represents a relatively surprising positive role for gene recruitment to the nuclear periphery. "The large extent of gene reorganization in response to a developmental switch is quite amazing and represents a new level of control that will have far reaching implications in, for example, generation of cell polarity in developing neurons," explains Dr. Silver.


Contact: Heather Cosel
Cold Spring Harbor Laboratory

Page: 1

Related biology news :

1. Location, location -- Cell sizes, lives influenced by host size
2. Location, location, location: Transcriptional activity and nuclear position
3. Effects of aging in stem cells
4. Malaria -- Effective insecticide-repellent synergy against mosquito vectors
5. Effective new biodiversity data access portal
6. PET/CT use expands: Effectively diagnosing graft infections
7. Effect on breast tumors of DNA alternations in 3 genes described
8. Effectiveness of certain antidepressants may be influenced by gene variations of individuals
9. Arctic Meltdown, Global Effects: Transatlantic Research Conference
10. Effects of nutrition on learning
11. UCF, NIH study: Effective, safe anthrax vaccine can be grown in tobacco plants

Post Your Comments:

(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global ... of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of ... located in Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions ... data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... hospitalized patients with severe COVID-19. This is the first study of an XPO1 ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... pleased to announce the next event in a series of TOPIQ webinars, which ... TOPIQ series of webinars was developed in response to social distancing measures that ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
Breaking Biology Technology:
Cached News: