HOME >> BIOLOGY >> NEWS
Location, location, location: Transcriptional activity and nuclear position

Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. By assaying the nuclear position and expression level of the beta globin locus during various stages of erythropoiesis, the researchers found that beta globin expression begins at the nuclear periphery, and as red blood cells mature, the beta globin locus progressively moves away from the nuclear periphery, towards the interior. Furthermore, they found that efficient relocalization is dependent upon the locus control region (LCR). Contrary to the existing dogma, this finding demonstrates that gene transcription precedes relocalization establishing the nuclear periphery as the new hot spot. Dr. Groudine emphasizes that "As recently shown in yeast, the nuclear periphery is a more complex compartment than thought. Clearly, determining the protein complexes associated with gene activation and repression at the nuclear periphery in mammalian cells is a high priority."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
17-May-2006


Page: 1

Related biology news :

1. Location, location -- Cell sizes, lives influenced by host size
2. Location, location, location: Effect of nuclear organization on transcriptional status
3. Eye candy: Transcriptional control of vertebrate eye development
4. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
5. Genes activity points to more lethal subtype of AML
6. Weizmann Institute scientists develop a general control switch for protein activity
7. Slow wave activity during sleep is lower in African-Americans than Caucasians
8. ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
9. Neuronal activity gives clues to working memory
10. CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
11. Hyperactivity and academic achievement could be linked by genetics

Post Your Comments:
(Date:2/5/2015)... , Jan. 26, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... corporate website ( http://www.nxt-id.com/ ) as part of its ... wallet. The Company launched its new consumer website for ... Pereira , CEO of NXT-ID said, "Our new corporate ...
(Date:2/5/2015)...  It is gratifying to see that the Obama ... science as a means to better understand human biology, ... was honored to participate in today,s White House event ... Since the 1980s my teams have been ... sequenced genome of a free living organism, the first ...
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2
(Date:2/26/2015)... Los Angeles, CA (PRWEB) February 26, 2015 ... organizing an online demonstration to support life extension technologies ... to 8pm UTC, Universal Coordinated Time, on March 21st ... around the world. , Eric Schulke, Founder of ... we must act with urgency. The Movement for Indefinite ...
(Date:2/26/2015)... BioEnterprise today announced that Northeast Ohio ... in growth funding during the past 13 years.  Funding ... – including the Ohio Third Frontier - and federal ... raised in the past five years. ... BioEnterprise Midwest Healthcare Growth Capital  Report.   ...
(Date:2/26/2015)... February 26, 2015 RURO, Inc., a ... FreezerPro® version 6.2 – the latest update to the ... is that of a quick and easy method to ... the latest version, RURO engineering has enhanced the system’s ... move large amounts of sample records. , "FreezerPro ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015 ... Gold Partner status in Oracle PartnerNetwork. In attaining Gold ... its commitment to establish Oracle-related knowledge in delivering Ceres, ... challenges of joint customers. Originally developed for ... to rapidly zoom in and out of massive amounts ...
Breaking Biology Technology:Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4RURO Releases FreezerPro® version 6.2 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4
Cached News: