HOME >> BIOLOGY >> NEWS
Location, location, location: Transcriptional activity and nuclear position

Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. By assaying the nuclear position and expression level of the beta globin locus during various stages of erythropoiesis, the researchers found that beta globin expression begins at the nuclear periphery, and as red blood cells mature, the beta globin locus progressively moves away from the nuclear periphery, towards the interior. Furthermore, they found that efficient relocalization is dependent upon the locus control region (LCR). Contrary to the existing dogma, this finding demonstrates that gene transcription precedes relocalization establishing the nuclear periphery as the new hot spot. Dr. Groudine emphasizes that "As recently shown in yeast, the nuclear periphery is a more complex compartment than thought. Clearly, determining the protein complexes associated with gene activation and repression at the nuclear periphery in mammalian cells is a high priority."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
17-May-2006


Page: 1

Related biology news :

1. Location, location -- Cell sizes, lives influenced by host size
2. Location, location, location: Effect of nuclear organization on transcriptional status
3. Eye candy: Transcriptional control of vertebrate eye development
4. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
5. Genes activity points to more lethal subtype of AML
6. Weizmann Institute scientists develop a general control switch for protein activity
7. Slow wave activity during sleep is lower in African-Americans than Caucasians
8. ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
9. Neuronal activity gives clues to working memory
10. CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
11. Hyperactivity and academic achievement could be linked by genetics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:4/28/2016)... , April 28, 2016 Infosys ... (NYSE: INFY ), and Samsung SDS, a global ... that will provide end customers with a more secure, fast ...      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... but it also plays a fundamental part in enabling and ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... San Francisco, CA (PRWEB) , ... June 23, ... ... capture (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase ... DIA Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting ...
Breaking Biology Technology:
Cached News: