HOME >> BIOLOGY >> NEWS
Location, location, location: Transcriptional activity and nuclear position

Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis. By assaying the nuclear position and expression level of the beta globin locus during various stages of erythropoiesis, the researchers found that beta globin expression begins at the nuclear periphery, and as red blood cells mature, the beta globin locus progressively moves away from the nuclear periphery, towards the interior. Furthermore, they found that efficient relocalization is dependent upon the locus control region (LCR). Contrary to the existing dogma, this finding demonstrates that gene transcription precedes relocalization establishing the nuclear periphery as the new hot spot. Dr. Groudine emphasizes that "As recently shown in yeast, the nuclear periphery is a more complex compartment than thought. Clearly, determining the protein complexes associated with gene activation and repression at the nuclear periphery in mammalian cells is a high priority."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
17-May-2006


Page: 1

Related biology news :

1. Location, location -- Cell sizes, lives influenced by host size
2. Location, location, location: Effect of nuclear organization on transcriptional status
3. Eye candy: Transcriptional control of vertebrate eye development
4. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
5. Genes activity points to more lethal subtype of AML
6. Weizmann Institute scientists develop a general control switch for protein activity
7. Slow wave activity during sleep is lower in African-Americans than Caucasians
8. ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
9. Neuronal activity gives clues to working memory
10. CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
11. Hyperactivity and academic achievement could be linked by genetics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... Calif. , April 18, 2017  Socionext Inc., a global ... of a media edge server, the M820, which features the company,s ... recognition software provided by Tera Probe, Inc., will be showcased during ... at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled a ... new look is part of a transformation to increase awareness, appeal to new markets ... It will also expand its service offering from its signature gourmet cooking classes and ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... ... , ... At its national board meeting in North Carolina, ARCS® Foundation ... of Physics and Astronomy, has been selected for membership in ARCS Alumni Hall ... 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of ...
(Date:10/7/2017)...  The 2017 Nobel Prize in Chemistry recognizes ... Joachim Frank and Richard Henderson ... (cryo-EM) have helped to broaden the use ... The winners worked with systems manufactured by Thermo ... resolved, three-dimensional images of protein structures that lead ...
Breaking Biology Technology:
Cached News: