HOME >> BIOLOGY >> NEWS
Looking for new approaches to target antibiotic-resistant bacteria

Infection with Entercoccus faecalis can cause bacterial endocarditis, an infection of the heart valves that if not treated with antibiotics results in death. The number of infections with antibiotic-resistant E. faecalis is increasing. So, researchers are looking for alternative strategies for treating individuals who become infected with this bacterium. Now, in a study appearing in the October issue of the Journal of Clinical Investigation, researchers from University of Texas Medical School at Houston have identified proteins that are required for E. faecalis to cause endocarditis in rats and that might make good vaccine candidates.

Barbara Murray and colleagues found that E. faecalis expresses four proteins that are required for the bacteria to form protein structures on their surface known as pili. The pili were required for the bacteria to aggregate and form biofilms. More importantly, rats infected with E. faecalis lacking expression of any one of these proteins suffered less severe bacterial endocarditis. This study, identifying E. faecalis proteins required for the bacterium to cause endocarditis in rats, might lead to the development of new strategies to treat individuals who become infected with E. faecalis.

In an accompanying commentary, Jonathan Budzik and Olaf Schneewind from the University of Chicago agree with this suggestion when they comment that, "This information may enable new vaccine strategies for the prevention of E. faecalis infections."


'"/>

Contact: Karen Honey
212-342-4159
Journal of Clinical Investigation
2-Oct-2006


Page: 1

Related biology news :

1. Looking for life on Jupiters icy moon Europa
2. Looking to a new era in bee research
3. Looking for consensus on how to manage metastatic breast cancer
4. Cold case: Looking for life on Mars
5. Looking at Eyeless from two directions
6. Hydrology, Politics, and Katrina: Looking Backward, and Going Forward
7. Looking for the genes that affect a persons level of response to alcohol
8. Looking at autoimmune diabetes, literally
9. New approaches to endometriosis treatment -- mouse experiments point the way
10. New understanding of schizophrenia could lead to new treatment approaches
11. Novel approaches to tackling obesity, cancer and MRSA

Post Your Comments:
(Date:4/17/2015)... April 17, 2015 ... and technological advancement to drive biometric systems market ... 2020   According to a recently ... Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... register growth at CAGR of over 22% through ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
(Date:4/23/2015)... April 23, 2015 Glemser ... the first EMC® Enterprise Content Division (ECD) Certified ... EMC Documentum® for Life Sciences Solution Suite ... knowledge and capabilities to provide life sciences companies ... , The EMC Documentum Solution Suite offers ...
(Date:4/23/2015)... YORK, NY , April 23, 2015 /PRNewswire/ - ... issued an Executive Informational Overview ® (EIO) on ... full 52-page report is available on Crystal Research Associates, ... as on Aeterna Zentaris, website at www.aezsinc.com . ... transitioning into a specialty biopharmaceutical company in oncology, endocrinology, ...
(Date:4/22/2015)... 22, 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... and accomplishments. For the first quarter ended ... of $5.3 million, or $0.08 per share, compared to ... share, for the same period in 2014. As of ... marketable securities and interest receivable of $226.1 million. ...
(Date:4/22/2015)... , April 22, 2015 Steep Hill, ... announced today that it has opened an investment ... growth and expansion.  The common stock investment round ... 506(c), a law intended to encourage funding of ... to 506(c), small businesses largely relied on friends ...
Breaking Biology Technology:Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3
Cached News: