HOME >> BIOLOGY >> NEWS
Loss of cell's 'antenna' linked to cancer's development

, the discovery that too much HEF1 and Aurora A cause cilia to disassemble provides important hints into what may be happening in cancers.

Defects in cilia have already been identified in one disease that represents a significant public health burden. Polycystic kidney disease, or PKD, arises from genetic mutations that cause flawed kidney-cell ciliary signaling. PKD is the most common serious hereditary disease, affecting more than 600,000 Americans and 12.5 million people worldwide.

In this incurable syndrome, patients develop numerous, fluid-filled cysts on the kidneys. For many patients, chronic pain is a common problem. PKD leads to kidney failure in about half of cases, requiring kidney dialysis or a kidney transplant.

The proteins involved in dismantling the cilia are no strangers to Golemis and her team. Golemis has been studying HEF1 for over a decade, since she first identified the gene. She first discovered that HEF1 has a role in controlling normal cell movement and tumor cell invasion. Golemis laboratory has also shown that Aurora A and HEF1 interact to initiate mitosis (chromosome separation) during cell division.

Suggestively, many cancers produce too much of the Aurora A protein, including breast and colorectal cancers and leukemia. In 2006, excessive production of HEF1 (also known as NEDD9) was found to drive metastasis in over a third of human melanomas, while HEF1 signaling also contributes to the aggressiveness of some brain cancers (glioblastomas).

Now theres a new activity for these proteins at cilia, said co-author Elizabeth P. Henske, M.D., a medical oncologist and genetics researcher who studies the genetic basis of kidney tumors. This complex HEF1 and Aurora A function may mean the increased levels of these proteins in cancer affect cellular response to multiple signaling pathways, rather like a chain reaction highway accident.

Clinical Application

The res
'"/>

Contact: Karen Mallet
Karen.Mallet@fccc.edu
215-728-2700
Fox Chase Cancer Center
28-Jun-2007


Page: 1 2 3

Related biology news :

1. Surprising origin of cells internal highways
2. Columbia scientists determine 3-dimensional structure of cells fuel gauge
3. Defective movement of cells power plants implicated in commom inherited neurological disorder
4. Johns Hopkins researchers find link between cells energy use and genome health
5. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
6. The closest look ever at the cells machines
7. New and sharper X-rays of cells ribosome could lead to better antibiotics
8. Scientists discover secret behind human red blood cells amazing flexibility
9. UCSB researchers discover that the cells endosomes use a surprising transportation system
10. Study shows how retinoic acid enters a cells nucleus
11. U-M researcher examines the cells housekeeping habits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... ... November 07, 2018 , ... The awards were presented ... science industry. The event was attended by 150 industry executives from leading life ... drug discovery. The winners were determined by responses to an online ballot completed ...
(Date:11/3/2018)... ... November 01, 2018 , ... The Conference Forum announces the ... 6-8, 2019 at the Crowne Plaza Times Square in New York City. , ... Genentech’s Global Franchise Leader in Cancer Immunotherapy Biomarkers and IO360° Plenary Chair, ...
(Date:11/3/2018)... ... 01, 2018 , ... As 2018 comes to a close, significant changes to ... quality systems for manufacturers worldwide. To mark World Quality Day this month, ... “While 2020 may sound far off, the May 26 deadline transition deadline that year ...
Breaking Biology News(10 mins):
(Date:11/3/2018)... ... November 01, 2018 , ... Come to Princeton Nov. ... Senior Advisor, Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on ... , What should clinical research industry stakeholders keep in mind when implementing and ...
(Date:10/31/2018)... ... October 30, 2018 , ... ... be a very important aspect of experimental biology. Reproducibility of cell-based assays is ... Despite of choosing the appropriate assay type, there are many more factors to ...
(Date:10/24/2018)... ... October 22, 2018 , ... uBiome, the leader in microbial ... Science Institute, Stephenson Chair of Data Science, and Professor in the Department of ... leading scientists and doctors from around the world, Dr. Bourne will bring to ...
(Date:10/18/2018)... ... October 18, 2018 , ... With rapid technological advances ... store their eggs. Previously reserved for women facing a cancer diagnosis requiring chemotherapy or ... to preserve their options. Simply put, they do not want to get pregnant ...
Breaking Biology Technology:
Cached News: