BOSTON -- Physicians monitoring patients who have undergone gastric bypass surgery should be on the alert for a new, potentially dangerous hypoglycemia (low blood glucose) complication that, while rare, may require quick treatment, according to a new study by collaborating researchers at Joslin Diabetes Center, Beth Israel Deaconess Medical Center (BIDMC), and Brigham and Women's Hospital (BWH) and published in the October issue of the journal Diabetologia. The paper follows on the heels of a Mayo Clinic report on six similar case studies published in July in the New England Journal of Medicine. About 160,000 people undergo gastric bypass surgery every year.
The study details the history of three patients, who did not have diabetes, who suffered such severe hypoglycemia following meals that they became confused and sometimes blacked out, in two cases causing automobile collisions. The immediate cause of hypoglycemia was exceptionally high levels of insulin following meals. All three patients in the collaborative study failed to respond to medication, and ultimately required partial or complete removal of the pancreas, the major source of insulin, to prevent dangerous declines in blood glucose.
"Severe hypoglycemia is a complication of gastric bypass surgery, and should be considered if the patient has symptoms such as confusion, lightheadedness, rapid heart rate, shaking, sweating, excessive hunger, bad headaches in the morning or bad nightmares," says Mary-Elizabeth Patti, M.D., Investigator in Joslin's Research Section on Cellular and Molecular Physiology and Assistant Professor of Medicine at Harvard Medical School. "If these symptoms don't respond to simple changes in diet, such as restricting intake of simple carbohydrates, patients should be evaluated hormonally, quickly," she adds. Dr. Patti and Allison B. Goldfine, M.D., also an Investigator at Joslin and Assistant Professor of Medicine at Harvard Medical School, were co-investigators of tPage: 1 2 3 Related biology news :1
Contact: Marjorie Dwyer
Joslin Diabetes Center
. High blood pressure, low energy -- a recipe for heart failure2
. Brain blood flow gives clues to treating depression3
. Study finds gender differences in renal and other genes contributing to blood pressure4
. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause5
. Research aims to identify markers for menopausal women at risk for deadly blood clot6
. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells7
. A low expression of MX2 gene exists in the white blood cells of narcoleptics8
. How a pain in the neck could be bad for your blood pressure9
. Penn researchers discover pathway that eliminates genetic defects in red blood cells10
. U-M team identifies gene that regulates blood-forming fetal stem cells11
. MicroRNA works with Ago2 protein to regulate blood cell development