HOME >> BIOLOGY >> NEWS
Low folate diets found to increase risk of colorectal cancer

A new study by scientists at the MUHC has revealed that a diet low in folate may increase the risk of developing colorectal cancer. Published in the scientific journal Cancer Research today, the study not only illustrates a way to prevent the disease but also provides further insight into the mechanisms of the disease, which could lead to novel therapies. Using animal models, the MUHC study is the first to demonstrate directly that diets low in folate cause colorectal cancer, and follows on the heels of earlier research by the same team that revealed how high folate diets can protect against heart disease.

"This research, which is consistent with previous epidemiological studies in humans, demonstrates a clear link between low dietary folate and the initiation of colorectal cancer in animal models," says Dr. Rima Rozen, Scientific Director of the Montreal Children's Hospital, Deputy Scientific Director of the MUHC, and lead investigator in the study. "None of the mice fed a control diet developed tumours whereas 1 in 4 mice on the folate-deficient diet developed at least one tumour."

Possible mechanisms of the disease were also investigated using molecular biological techniques. "The study shows that a low level of dietary folate may cause an increase in DNA damage, which plays a role in the development of tumours," noted Dr. Rozen. The study also reveals that folate deficiency causes genes which usually respond to DNA damage to behave abnormally, also contributing to the development of tumours. The results suggest that a diet containing sufficient folate may reduce the risk of developing colorectal cancer.

"It is estimated that 20,000 men and women will be diagnosed with colorectal cancer this year, and an estimated 8,500 will die from the disease. The result of this study highlights how simply adding a supplement to your daily diet could have tremendous long-term benefits to the individual and the health care system," said Dr. Phil
'"/>

Contact: Ian Popple
ian.popple@muhc.mcgill.ca
514-843-1560
McGill University
2-Nov-2006


Page: 1 2

Related biology news :

1. Dietary vitamin B6, B12 and folate, may decrease pancreatic cancer risk among lean people
2. Scientists genetically engineer tomatoes with enhanced folate content
3. High cholesterol diets modify gene expression in atherosclerosis
4. Simulating human metabolism to find new diets to new drugs
5. How protein-rich diets curb hunger
6. Ancient diets of Australian birds point to big ecosystem changes
7. Link between mothers poor diets, kids obesity
8. Antioxidant-rich diets reduce brain damage from stroke in rats
9. Panel discusses effect of individualized diets on chronic disease risk
10. Waters off Washington state only second place in world where glass sponge reefs found
11. First new multiple sclerosis gene found in 30 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: