HOME >> BIOLOGY >> NEWS
MBL study shows how good cholesterol (HDLs) provide human immunity to certain parasites

MBL, WOODS HOLE, MA -- For years biomedical researchers have known that high density lipoproteins, commonly called HDLs or "good cholesterol," are responsible for protecting humans from certain parasites, but couldn't explain how. Now MBL scientists have discovered that human HDLs work this bug-repelling magic by serving as a platform for the assembly and delivery of two naturally occurring proteins that combine to create a super-toxic antimicrobial.

The research, published in the September 30 issue of the Journal of Biological Chemistry, focuses specifically on human innate immunity to Trypanosoma brucei brucei, the parasite that gives African cattle the deadly disease called Nagana, but which doesn't harm humans even though scientists believe they are exposed to it. The parasite is a close relative of Trypanosoma brucei gambienese and Trypanosoma brucei rhodesiense, the organisms that cause African sleeping sickness in humans.

The findings that two proteins work synergistically to kill the Nagana parasite in humans contradict a long-held hypothesis that a single protein was the key to HDL's parasite-fighting power. "The research may be helpful to veterinarians hoping to develop treatments to aid African cattle farmers, who lose three million cattle and around a billion US dollars annually to Nagana," says April Shiflett, a scientist in the MBL's Global Infectious Diseases Program and an author on the paper. Scientists also hope the research will provide key information to investigators seeking treatments for certain parasitic infections, such as malaria.

To identify the proteins--known as apolipoprotein L-1 (apo L-1) and haptoglobin-related protein (Hpr)--MBL scientists tested different amounts and combinations of the proteins on Trypanosoma brucei brucei specimens. To survive the parasite needs to digest the lipids in HDLs. Because HDL carries these proteins and enables them to combine, it is nature's perfect delivery system for the an
'"/>

Contact: Gina Hebert
ghebert@mbl.edu
508-289-7725
Marine Biological Laboratory
28-Oct-2005


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... EGG HARBOR, N.J. (PRWEB) , ... March 13, 2019 , ... ... detection systems for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited to announce ... changed ownership in early February 2019 and the newly installed and highly experienced ...
(Date:3/11/2019)... ... 11, 2019 , ... A new report published by the Family Equality Council ... 77% of those aged 18 to 35 already have or are considering having children, ... and older.(1) Among all LGBTQ prospective parents, 41% are considering assisted reproductive technology (ART) ...
(Date:3/9/2019)... MURRIETA, Calif. (PRWEB) , ... March 07, 2019 , ... ... sponsor of a full day workshop presented by University of California Riverside’s ... being held from 8 a.m. to 6 p.m. on Tuesday, March 17, 2019. The ...
Breaking Biology News(10 mins):
(Date:3/12/2019)... (PRWEB) , ... March 11, 2019 , ... ... first hospital system in Colorado, and among the first in the nation, to ... around lab draws, IV placement and overall degree to which staff showed compassion ...
(Date:3/9/2019)... ... March 07, 2019 , ... ACEA Biosciences Inc. ... and commercialization of high performance, cutting-edge cell analysis platforms for life science research. ... expertise in cardiovascular pharmacology and electrophysiology, are announcing a partnership to provide comprehensive ...
(Date:3/4/2019)... ... 04, 2019 , ... Stay on top of current hot topics through free webinars presented by ... free, so be sure to register today to save your place! Participate in the discussion ... webinars: , CLINICAL TRIALS, , March 20 – Implementing BYOD Across ...
(Date:2/22/2019)... , ... February 20, 2019 , ... ... SeqOnce , an emerging leader in the rapidly growing NGS (Next Generation Sequencing) ... the Murrieta Genomics laboratory and incubator. , "As an innovation center and idea ...
Breaking Biology Technology:
Cached News: