HOME >> BIOLOGY >> NEWS
MGH researchers confirm that bone marrow restores fertility in female mice

A new study from Massachusetts General Hospital (MGH) researchers confirms that female mice that receive bone marrow transplantation after fertility-destroying chemotherapy can go on to have successful pregnancies throughout their normal reproductive life. The report in the August 1 Journal of Clinical Oncology verifies that donor marrow can restore fertility in female mice through an as-yet unidentified mechanism. While donor-derived egg cells or oocytes were observed in the ovaries of marrow recipients, all pups born were from the recipients own eggs.

Consistent with our past work, cells derived from the donor bone marrow are getting into the ovaries and developing into immature oocytes, says Jonathan Tilly, PhD, director of the Vincent Center for Reproductive Biology (www.vcrb.org) at MGH, the studys senior author. Although these oocytes derived from marrow cells dont appear competent, at least thus far, to make fertilizable eggs, marrow does contribute something that allows a resumption of fertility in female mice sterilized by chemotherapy.

In a 2005 paper published in the journal Cell, Tillys group found that the ovaries of female mice that had received bone marrow or blood cell transplants after fertility-destroying doses of chemotherapy appeared normal and contained immature oocytes expressing a marker protein indicating they came from the donor cells. This report followed a 2004 Nature paper, also from Tillys team, reporting that female mice continued producing eggs well into adulthood, in contrast to the long-held belief that female mammals are born with a finite supply of eggs that is depleted throughout life. Both those papers have been extremely controversial, and the current study was designed to follow up the 2005 paper and to address criticisms raised by other researchers.

In the current study, adult female mice treated with infertility-inducing chemotherapy received bone marr
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
31-Jul-2007


Page: 1 2 3 4

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
10. U-M researchers identify gene involved in breast cancer
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... LAKE CITY, and MARTINSRIED, Germany (PRWEB) , ... ... ... in high-throughput antibody screening and characterization, announced today that they have opened a ... Carterra’s platform has fueled the need for the new office. , The Munich ...
(Date:8/14/2019)... JOLLA, Calif. (PRWEB) , ... August 14, 2019 , ... ... insight into their future children, announces inclusion in the 38th annual Inc. 500|5000 ... been eligible to apply. To qualify, companies must have been founded and generating revenue ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to ... patients will visit urgent care centers (UCC) in the coming years, according to a ... The Market for Urgent Care Centers , is a detailed look at the current ...
Breaking Biology News(10 mins):
(Date:9/2/2019)... DENVILLE, N.J. and LIÉGE, Belgium (PRWEB) , ... ... ... provider of solutions for epigenetics research and in vitro diagnostics, has launched the ... to uncover the underlying biological meaning of epigenetic data and other data ...
(Date:8/29/2019)... ... August 29, 2019 , ... ... in the Sustainable Medicines in Africa program, which includes a master’s degree in ... Arusha, Tanzania September 2nd through 13th, 2019. Topics to be addressed include ...
(Date:8/25/2019)... VEGAS (PRWEB) , ... August 23, 2019 , ... ... with International No. 1 best-selling status for the scientific research book “Impact of ... in the cosmetic and perfume industry as Patchouli. , The book garnered ...
(Date:8/15/2019)... (PRWEB) , ... August 15, 2019 , ... ... Scientific Advisory Board. Mr. Lawrence is a member of the Institute of Food ... Safety and Health (IFSH) Advisory Board, Joint Institute for Food Safety and Applied ...
Breaking Biology Technology:
Cached News: