HOME >> BIOLOGY >> NEWS
MIT, Brigham: Nanoparticles armed to combat cancer

CAMBRIDGE, Mass.--Ultra-small particles loaded with medicine - and aimed with the precision of a rifle - are offering a promising new way to strike at cancer, according to researchers working at MIT and Brigham and Women's Hospital.

In a paper to appear the week of April 10 in the online edition of the Proceedings of the National Academy of Sciences, the team reports a way to custom design nanoparticles so they home in on dangerous cancer cells, then enter the cells to deliver lethal doses of chemotherapy. Normal, healthy cells remain unscathed.

The team conducted experiments first on cells growing in laboratory dishes, and then on mice bearing human prostate tumors. The tumors shrank dramatically, and all of the treated mice survived the study; the untreated control animals did not.

"A single injection of our nanoparticles completely eradicated the tumors in five of the seven treated animals, and the remaining animals also had significant tumor reduction, compared to the controls," said Dr. Omid C. Farokhzad, an assistant professor at Brigham and Women's Hospital and Harvard Medical School.

Farokhzad and MIT Institute Professor Robert Langer led the team of eight researchers. (Farokhzad was formerly a research fellow in Langer's lab.)

The scientists said that further testing is needed. Although all the parts and pieces of their new system are known to be safe, the system itself must yet be proven safe and effective in humans. This means thorough testing must be done in larger animals, and eventually in humans.

"We're most interested in developing a system that ends up in the clinic helping patients," Farokhzad said. To make that happen, he added, "we brought in cancer specialists and urologists to collaborate with us."

Further, he said, from an engineering perspective "we wanted to develop a broadly applicable system, one that other investigators can alter for their own purposes."

For example, Lang
'"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
10-Apr-2006


Page: 1 2

Related biology news :

1. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
2. Nanoparticles carry chemotherapy drug deeper into solid tumors
3. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
4. Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
5. Nanoparticles for delivery of prostate cancer treatment
6. Nanoparticles create biocompatible capsules
7. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
8. Farmed salmon could become an invasive species in forest streams
9. African wetland managers armed with new technology
10. Escapee farmed salmon infiltrate fitter wild populations
11. Risk/benefit analysis of farmed versus wild salmon

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan has joined ... , Dr. Canan previously served as Executive Director of Global Health at Bristol ...
(Date:8/26/2020)... ... August 25, 2020 , ... Catalent, the leading ... cell and gene therapies, and consumer health products, today announced that two Catalent ... & Expo, taking place between Aug. 31 – September 4, 2020. , On ...
(Date:8/23/2020)... WOODLANDS, Texas (PRWEB) , ... August 21, 2020 ... ... from Rigaku Corporation has been published and is now available on ... single crystal X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic ...
Breaking Biology News(10 mins):
(Date:9/3/2020)... LOUIS, Mo. (PRWEB) , ... September 03, 2020 ... ... 10-11, 2020, will feature 15+ expert speakers to present updates on their latest ... will highlight innovative technologies and their impact in clinical diagnostics and therapeutic development, ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... diagnostics companies, has announced the placement of Julianne Averill , CPA, as ... leading all financial operations and implementing key business strategies to accelerate Alveo’s growth ...
(Date:8/31/2020)... Del. (PRWEB) , ... August 29, 2020 , ... ... a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant operation ... global quality standards and advanced technology. , “This facility will improve the ...
(Date:8/15/2020)... ... ... True Terpenes , the leading platform for terpene innovation, research and ... the medical potential of terpenes and the potential entourage effect , where the ... focused on expanding the recently launched line of effects-based terpenes - Terpology by ...
Breaking Biology Technology:
Cached News: